(R)-1-(4-bromo-1H-pyrazol-1-yl)-2-(6-methoxynaphthalen-2-yl)propan-1-one | 1312025-25-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (R)-1-(4-bromo-1H-pyrazol-1-yl)-2-(6-methoxynaphthalen-2-yl)propan-1-one
• CAS: 1312025-25-4
• 化学式: C₁₇H₁₅BrN₂O₂
• 分子量: 359.222
• InChiKey: BYOFMTGWKBEOKX-LLVKDONJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.25
• 重原子数：
  22.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  44.12
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  甲醇 、 (R,S)-naproxenyl 4-bromopyrazolide 在 Candida rugosa lipase MY 作用下， 以 异辛烷 为溶剂， 反应 10.0h， 生成 (R)-1-(1H-imidazol-1-yl)-2-(6-methoxynaphthalen-2-yl)propan-1-one 、 (R)-1-(4-bromo-1H-pyrazol-1-yl)-2-(6-methoxynaphthalen-2-yl)propan-1-one
  参考文献：
  名称：

  Improvements of enzyme activity and enantioselectivity in lipase-catalyzed alcoholysis of (R,S)-azolides

  摘要：

  With Candida antarctica lipase B (CALB)-catalyzed alcoholysis of (R,S)-naproxenyl 1,2,4-triazolide at the optimal conditions (i.e. anhydrous MTBE as the solvent, and methanol as the acyl acceptor at 45 degrees C) as the model system, the enzyme enantioselectivity in terms of V-R/V-S = 105.8 and specific activity for the fast-reacting (R)-azolide V-R/(E-t) = 0.979 mmol/(h g) were greatly improved in comparison with V-R/V-S = 8.0 and V-R/(E-t) = 0.113 mmol/(h g) of using (R,S)-naproxenyl 2,2,2-trifluoroethyl ester as the substrate. The resolution strategy was successfully extended to other (R,S)-profenyl 1,2,4-triazolides and lipases from Candida rugosa (Lipase MY) and Carica papaya (CPL) having opposite enantioselectivity to CALB. Moreover, the kinetic constants were estimated, compared with those obtained via hydrolysis, and employed for modeling time-course conversions of (R,S)-naproxenyl 1,2,4-triazolide in anhydrous MTBE. The advantages of easy substrate preparation, high enzyme reactivity and enantioselectivity, as well as easy product separation from the remaining substrate via reactive extraction demonstrate merits of using (R,S)-azolides but not the corresponding esters for the alcoholytic resolution. (C) 2009 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molcatb.2009.11.001

文献信息

• Kinetic resolution of (R,S)-pyrazolides containing substituents in the leaving pyrazole for increased lipase enantioselectivity
  作者：Pei-Yun Wang、Chia-Hui Wu、Jyun-Fen Ciou、An-Chi Wu、Shau-Wei Tsai

  DOI：10.1016/j.molcatb.2010.04.003

  日期：2010.9

  With hydrolysis of (R,S)-azolides in water-saturated methyl tert-butyl ether (MTBE) via Candida antarctica lipase B (CALB) as the model system, (R,S)-pyrazolides containing a leaving 3-, 4- or 3,4-substituted-pyrazole moiety are selected as the best substrates for preparing various optically pure carboxylic acids containing an α-chiral center. Great improvements of enzyme activity for the (R)-enantiomers

  以南极假丝酵母脂肪酶B（CALB）为模型体系，通过水饱和的甲基叔丁基醚（MTBE）中的（R，S）-吡咯内酯水解为模型系统，其中含有（R，S）-吡唑并含有3-，4-选择3，4-或3，4-取代的吡唑部分作为制备各种含有α-手性中心的光学纯羧酸的最佳底物。对于（酶活性的很大的改进- [R ）具有优异的对映选择性-对映体（V - [R / V小号 > 100）可获得，如果（[R ，小号含有留下的3-或3,4-取代的吡唑部分的R-吡唑化物用于在无水MTBE中由甲醇水解或醇解。对（R，S）-N -2-苯基丙酰基吡唑的详细动力学分析表明，在离开的吡唑部分中较大的3-取代基（例如3-（3-溴苯基）或3-（2-吡啶基））对降低无水MTBE中反应缓慢的对映异构体的催化丝氨酸的亲核攻击和质子转移，以及水饱和MTBE中两种对映异构体的亲和性和底物亲和力。该拆分平台还成功应用于通过水饱和的环己烷中的（R，S）-吡唑