carbonato(1,2-diaminocyclohexane)platinum | 63037-39-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: carbonato(1,2-diaminocyclohexane)platinum
• CAS: 63037-39-8；76583-21-6
• 化学式: C₇H₁₄N₂O₃Pt
• 分子量: 369.28
• InChiKey: DZNVQIBVSPRPAU-RUTFAPCESA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  carbonato(1,2-diaminocyclohexane)platinum 、 水杨酸 以 乙醇 为溶剂， 以43.7%的产率得到salicylato(1,2-diaminocyclohexane)platinum(II)
  参考文献：
  名称：

  The thermal degradation characteristics of selected organoplatinum antitumor agents

  摘要：

  The thermal decomposition characteristics of representatives of three classes of organoplatinum compounds have been examined by thermogravimetry. Substituted salicylato(1,2-diaminocyclohexane)platinum(II) compounds undergo thermal decomposition by sequential loss of first the salicylato ligand and then the amine ligand to afford a residue corresponding to the platinum content of the compound. The thermal decomposition of N-arylsalicylaldimino(1,2-diaminocyclohexane)platinum(II) nitrate is more complex, but is also characterized by two major weight losses. Thermal decomposition of bis-(2-thiophenecarboxylato)platinum(II) is characterized by ligand fragmentation to generate a residual mass corresponding to the platinum content of the compound.

  DOI：

  10.1007/bf02546607
• 作为产物：
  描述：

  [SP-4-2-(1R-反式)]-(1,2-环己烷二胺-N,N')二氯化物铂(II) 、 silver carbonate 生成 carbonato(1,2-diaminocyclohexane)platinum
  参考文献：
  名称：

  The thermal degradation characteristics of selected organoplatinum antitumor agents

  摘要：

  The thermal decomposition characteristics of representatives of three classes of organoplatinum compounds have been examined by thermogravimetry. Substituted salicylato(1,2-diaminocyclohexane)platinum(II) compounds undergo thermal decomposition by sequential loss of first the salicylato ligand and then the amine ligand to afford a residue corresponding to the platinum content of the compound. The thermal decomposition of N-arylsalicylaldimino(1,2-diaminocyclohexane)platinum(II) nitrate is more complex, but is also characterized by two major weight losses. Thermal decomposition of bis-(2-thiophenecarboxylato)platinum(II) is characterized by ligand fragmentation to generate a residual mass corresponding to the platinum content of the compound.

  DOI：

  10.1007/bf02546607

文献信息

• Synthesis and characterization of Pt complexes containing dichloroacetate (DCA), designed for dual anticancer action
  作者：Valeria Ferretti、Paola Bergamini、Lorenza Marvelli、Yekatsiaryna Hushcha、Chiara Gemmo、Roberto Gambari、Ilaria Lampronti

  DOI：10.1016/j.ica.2017.04.048

  日期：2018.1

  dichloroacetate (DCA), bearing DMSO ( cis -[Pt(DCA) 2 (Me 2 SO -S ) 2 ], 2 ) or phosphines ( cis -[Pt(DCA) 2 (PPh 3 )(Me 2 SO -S )], 3 , cis -[Pt(DCA) 2 (P) 2 ], P = PPh 3 3a , P = PTA 4a and [Pt(DCA)(P) 3 ]DCA, P = PPh 3 3b , P = PTA, 4b ) as neutral ligands was prepared by a simple fast route from the inorganic synthon [PtCO 3 (Me 2 SO -S ) 2 ], 1 . The X-ray crystal structures of 2 , 3 , 3a and 4a were

  摘要一组新的带有二氯乙酸酯（DCA）的Pt（II）配合物，带有DMSO（顺式-[Pt（DCA）2（Me 2 SO -S）2]，2）或膦（顺式-[Pt（DCA）2） （PPh 3）（Me 2 SO -S）]，3，顺式-[Pt（DCA）2（P）2]，P = PPh 3 3a，P = PTA 4a和[Pt（DCA）（P）3]通过简单的快速路线从无机合成子[PtCO 3（Me 2 SO -S）2]，1制备作为中性配体的DCA，P = PPh 3 3b，P = PTA，4b）。确定了2、3、3a和4a的X射线晶体结构。评价了2，4a和4b对两种人癌细胞系顺铂敏感的A2780和顺铂耐药的SKOV-3的抗增殖活性，并将结果与​​已知的胺类似物和二氯化物前体进行了比较。