ethyl 7-(1H-imidazol-1-yl)-2-naphthalencarboxylate | 95355-05-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: ethyl 7-(1H-imidazol-1-yl)-2-naphthalencarboxylate
• 英文别名: Ethyl 7-imidazol-1-ylnaphthalene-2-carboxylate
• CAS: 95355-05-8
• 化学式: C₁₆H₁₄N₂O₂
• 分子量: 266.299
• InChiKey: VIQTWNXCQWJTEF-UHFFFAOYSA-N

物化性质

• 沸点：
  458.1±18.0 °C(Predicted)
• 密度：
  1.19±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  44.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  ethyl 7-(1H-imidazol-1-yl)-2-naphthalencarboxylate 在 氢氧化钾 作用下， 以2.17 g的产率得到7-咪唑-1-基萘-2-羧酸
  参考文献：
  名称：

  N-imidazolyl derivatives of the napththalene and chroman rings as thromboxane A2 synthase inhibitors

  摘要：

  A series of N-imidazol-1-yl derivatives of 1,2-dihydronaphthalene, 1,2,3,4-tetrahydronaphthalene, 2H-1-benzopyran and some related compounds were synthesized and tested as inhibitors of thromboxane A2 synthase in ex vivo experiments with orally treated rats. Some compounds showed good activity which was confirmed in experiments in vitro in rabbit whole blood. Some structural requirements for significant TxA2 synthase inhibitory activity are discussed. The selected 5,6-Dihydro-7-(H-1-imidazol-1-yl)-2-naphthalene-carboxylic acid (compound 7) was conformationally analysed using the Sybyl molecular model system in comparison with dazoxiben. Compound 7 was further pharmacologically investigated and on the basis of its interesting activities in vitro, ex vivo and in vivo and its low toxicity was selected for clinical investigation.

  DOI：

  10.1016/0223-5234(91)90103-t
• 作为产物：
  描述：

  ethyl 5,6-dihydro-7-(1H-imidazol-1-yl)-2-naphthalene carboxylate 在 sulfur 作用下， 反应 8.0h， 以2.67 g的产率得到ethyl 7-(1H-imidazol-1-yl)-2-naphthalencarboxylate
  参考文献：
  名称：

  N-imidazolyl derivatives of the napththalene and chroman rings as thromboxane A2 synthase inhibitors

  摘要：

  A series of N-imidazol-1-yl derivatives of 1,2-dihydronaphthalene, 1,2,3,4-tetrahydronaphthalene, 2H-1-benzopyran and some related compounds were synthesized and tested as inhibitors of thromboxane A2 synthase in ex vivo experiments with orally treated rats. Some compounds showed good activity which was confirmed in experiments in vitro in rabbit whole blood. Some structural requirements for significant TxA2 synthase inhibitory activity are discussed. The selected 5,6-Dihydro-7-(H-1-imidazol-1-yl)-2-naphthalene-carboxylic acid (compound 7) was conformationally analysed using the Sybyl molecular model system in comparison with dazoxiben. Compound 7 was further pharmacologically investigated and on the basis of its interesting activities in vitro, ex vivo and in vivo and its low toxicity was selected for clinical investigation.

  DOI：

  10.1016/0223-5234(91)90103-t

文献信息

• COZZI, P.;CARGANICO, G.;PILLAN, A.;BRANZOLI, U.
  作者：COZZI, P.、CARGANICO, G.、PILLAN, A.、BRANZOLI, U.

  DOI：——

  日期：——