N-((2-bromophenyl)(2-hydroxynaphthalen-1-yl)methyl)acetamide | 1010729-00-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-((2-bromophenyl)(2-hydroxynaphthalen-1-yl)methyl)acetamide
• 英文别名: N-[(2-bromophenyl)-(2-hydroxynaphthalen-1-yl)methyl]acetamide
• CAS: 1010729-00-6
• 化学式: C₁₉H₁₆BrNO₂
• 分子量: 370.246
• InChiKey: YVYGJJFOCDTSRJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  乙酰胺 、 邻溴苯甲醛 、 2-萘酚 在 dodecylphosphonic acid 作用下， 反应 0.33h， 以88%的产率得到N-((2-bromophenyl)(2-hydroxynaphthalen-1-yl)methyl)acetamide
  参考文献：
  名称：

  Eco-friendly and efficient multi-component method for preparation of 1-amidoalkyl-2-naphthols under solvent-free conditions by dodecylphosphonic acid (DPA)

  摘要：

  个人简历 使用多组分一锅煮缩合反应，在无溶剂条件下，以十二烷基膦酸作为催化剂，实现β-萘酚、芳香或脂肪醛和苯甲酰胺或乙酰胺制备1-酰胺基烷基-2-萘酚的高效、直接环保合成方法。

  DOI：

  10.1016/j.crci.2011.11.012

文献信息

• Efficient One-Pot Syntheses of Betti Bases Catalyzed by 1-Methyl-3-(2-(sulfooxy)ethyl)-1<i>H</i>-imidazol-3-ium Chloride
  作者：C. Wang、Y. Wan、H.-Y. Wang、L.-L. Zhao、J.-J. Shi、X.-X. Zhang、H. Wu

  DOI：10.1002/jhet.1124

  日期：2013.5

  The efficient one‐pot syntheses of Betti bases by the three‐component reaction of aromatic aldehyde, 2‐naphthalen, and acetonitrile (or benzamide) catalyzed by 1‐methyl‐3‐(2‐(sulfooxy)ethyl)‐1H‐imidazol‐3‐ium chloride is reported. The solvent can be recycled easily.

  通过1-甲基-3-（2-（磺氧基）乙基）-1H-咪唑催化的芳香醛，2-萘和乙腈（或苯甲酰胺）的三组分反应有效地一锅合成Betti碱报道了氯化三 该溶剂可以容易地回收。
• Boric acid as a mild and efficient catalyst for one-pot synthesis of 1-amidoalkyl-2-naphthols under solvent-free conditions
  作者：AZIZ SHAHRISA、SOMAYEH ESMATI、MAHDI GHOLAMHOSSEINI NAZARI

  DOI：10.1007/s12039-012-0285-6

  日期：2012.7

  green chemistry method has been developed for the synthesis of 1-amidoalkyl-2-naphthol derivatives via a one-pot three-component condensation of 2-naphthol, aldehydes and amide in the presence of boric acid as a mild catalyst. An efficient green chemistry method has been developed for the synthesis of 1-amidoalkyl-2-naphthol derivatives via a one-pot three-component condensation of 2-naphthol, aldehydes

  已经开发出一种有效的绿色化学方法，用于在硼酸作为温和催化剂的情况下，通过2-萘酚，醛和酰胺的一锅式三组分缩合反应合成1-酰胺基烷基-2-萘酚衍生物。 已经开发出一种有效的绿色化学方法，用于在硼酸作为温和催化剂的情况下，通过2-萘酚，醛和酰胺的一锅式三组分缩合反应合成1-酰胺基烷基-2-萘酚衍生物。
• Zirconyl triflate as an efficient and reusable catalyst for one-pot synthesis of 1-amidoalkyl-2-naphthols under solvent-free conditions
  作者：Hajar Hashemi、Ali Reza Sardarian

  DOI：10.1007/s13738-012-0208-y

  日期：2013.8

  In the present work, the preparation of 1-amidoalkyl-2-naphthols via one-pot three-component condensation of amides, aldehydes, and β-naphthol in the presence of catalytic amounts of zirconyl triflate, as a highly efficient, low toxic, stable and non-hygroscopic catalyst under solvent-free conditions is reported. This low-cost procedure offers several other advantages such as short reaction times and

  在目前的工作中，在催化量的三氟甲磺酸锆存在下，通过酰胺，醛和β-萘酚的一锅式三组分缩合反应制备1-氨基烷基-2-萘酚，是一种高效，低毒，报告了在无溶剂条件下稳定且不吸湿的催化剂。这种低成本的方法还具有其他优点，例如反应时间短，产率高至优异。
• Preparation and characterization of nano‐Co‐[4‐chlorophenyl‐salicylaldimine‐methyl pyranopyrazole]Cl₂as a new Schiff base complex and catalyst for the solvent‐free synthesis of 1‐amidoalkyl‐2‐naphthols
  作者：Ahmad Reza Moosavi‐Zare、Hamid Goudarziafshar、Fatemeh Nooraei

  DOI：10.1002/aoc.5252

  日期：2020.1

  By the reaction of 4‐chlorobenzaldehyde with ethyl acetoacetate, malononitrile, and hydrazine hydrate, 6‐amino‐4‐(4‐chlorophenyl)‐3‐methyl‐2,4‐dihydropyrano[2,3‐c]pyrazole‐5‐carbonitrile was prepared and then reacted with salicylaldehyde and CoCl2·6H2O to produce nano‐Co‐[4‐cholorophenyl‐salicylaldimine‐methylpyranopyrazole]Cl2 (nano‐[Co‐4CSMP]Cl2). The prepared nano‐Schiff base complex was reported

  通过4-氯苯甲醛与乙酰乙酸乙酯，丙二腈和水合肼的反应，生成6-氨基-4-（4-氯苯基）-3-甲基-2-，4-二氢吡喃[2,3-c]吡唑-5-碳腈制备后与水杨醛和CoCl 2 ·6H 2 O反应生成纳米-Co- [4--氯苯基-水杨基醛二胺-甲基吡喃并吡唑] Cl 2（纳米[Co-4CSMP] Cl 2）。首次报道了制备的纳米席夫碱复合物，并通过傅里叶变换红外光谱，热重分析，差示热重分析，扫描电子显微镜，能量色散X射线光谱，透射电子显微镜和Brunner进行了全面表征。 –Emmett–Teller分析并将其用作合成某些1-氨基烷基-2-萘酚衍生物的有效催化剂。
• An Improved Synthesis of Amidoalkyl Phenols Involving a Ritter-Type Reaction
  作者：Biswanath Das、Keetha Laxminarayana、P. Thirupathi、B. Ramarao

  DOI：10.1055/s-2007-990923

  日期：——

  Three-component condensation of phenols, aromatic aldehydes and alkyl nitriles in the presence of a catalytic amount of triflic acid yielded the corresponding amidoalkyl phenols involving a Ritter-type reaction. The products were formed in high yields and in short reaction times.

  在催化量的三氟甲磺酸存在下，苯酚、芳香醛和烷基腈的三组分缩合产生相应的酰胺烷基苯酚，涉及 Ritter 型反应。产物以高产率和短反应时间形成。