1-(2,2,2-trifluoroethyl)piperidin-4-one hydrochloride | 710350-67-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-(2,2,2-trifluoroethyl)piperidin-4-one hydrochloride
• 英文别名: 1-(2,2,2-trifluoroethyl)piperidin-4-one;hydrochloride
• CAS: 710350-67-7
• 化学式: C₇H₁₀F₃NO*ClH
• 分子量: 217.619
• InChiKey: CZUQVRGYCWCWOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.64
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  20.3
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-(2,2,2-trifluoroethyl)piperidin-4-one hydrochloride 、 氰化钾 在 氯化铵 、 氨 作用下， 以 水 、 甲醇 为溶剂， 反应 60.0h， 生成 4-amino-1-(2,2,2-trifluoroethyl)piperidine-4-carbonitrile hydrochloride
  参考文献：
  名称：

  WO2006/60494

  摘要：

  公开号：
• 作为产物：
  描述：

  8-(2,2,2-trifluoroethyl)-1,4-dioxa-8-azaspiro[4.5]-decane 在 盐酸 作用下， 以 水 、 丙酮 为溶剂， 反应 12.0h， 生成 1-(2,2,2-trifluoroethyl)piperidin-4-one hydrochloride
  参考文献：
  名称：

  [EN] HALOALKYL CONTAINING COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS
  [FR] COMPOSES CONTENANT UN HALOALKYLE UTILISE COMME INHIBITEURS DE CYSTEINE PROTEASE

  摘要：

  公开号：

  WO2005028429A3

文献信息

• Cyanomethyl derivatives as cysteine protease inhibitors
  申请人：Graupe Michael

  公开号：US20060122184A1

  公开（公告）日：2006-06-08

  The present invention is directed to cyanomethyl derivatives that are inhibitors of cysteine protease, in particular, cathepsin B, K, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.

  本发明涉及氰甲基衍生物，其是半胱氨酸蛋白酶的抑制剂，特别是对于B、K、F和S型的卡特普辛，因此可用于治疗由这些蛋白酶介导的疾病。本发明还涉及包含这些化合物的制药组合物和其制备过程。
• Haloalkyl containing compounds as cysteine protease inhibitors
  申请人：Link O. John

  公开号：US20050182096A1

  公开（公告）日：2005-08-18

  The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.

  本发明涉及抑制半胱氨酸蛋白酶的化合物，特别是cathepsins B、K、L、F和S，因此可用于治疗由这些蛋白酶介导的疾病。本发明涉及包含这些化合物的药物组合物和制备它们的过程。
• Haloalkyl Containing Compounds as Cysteine Protease Inhibitors
  申请人：Setti Eduardo L.

  公开号：US20090023781A1

  公开（公告）日：2009-01-22

  The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.

  本发明涉及一种抑制半胱氨酸蛋白酶的化合物，特别是cathepsins B、K、L、F和S，因此可用于治疗由这些蛋白酶介导的疾病。本发明涉及包含这些化合物的制药组合物和制备它们的过程。
• Processes and Intermediates Preparing Cysteine Protease Inhibitors
  申请人：Li Jiayao

  公开号：US20080114175A1

  公开（公告）日：2008-05-15

  The present invention is directed to a process for preparing certain cysteine protease inhibitors.

  本发明涉及一种制备某些半胱氨酸蛋白酶抑制剂的过程。
• Processes and intermediates preparing cysteine protease inhibitors
  申请人：ViroBay, Inc.

  公开号：US07737300B2

  公开（公告）日：2010-06-15

  The present invention is directed to a process for preparing certain cysteine protease inhibitors.

  本发明涉及一种制备特定半胱氨酸蛋白酶抑制剂的过程。