4-[1-(3,4-diethoxyphenyl)-6,7-diethoxy-3-oxo-3,4-dihydroisoquinolin-2(1H)-yl]benzoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 4-[1-(3,4-diethoxyphenyl)-6,7-diethoxy-3-oxo-3,4-dihydroisoquinolin-2(1H)-yl]benzoic acid
• 英文别名: 4-[1-(3,4-diethoxyphenyl)-6,7-diethoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]benzoic acid
• 化学式: C₃₀H₃₃NO₇
• 分子量: 519.6
• InChiKey: BKWBUUYCHYLRLF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  38
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  94.5
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Prevention and treatment of inflammation-induced and/or immune-mediated bone loss
  申请人：onepharm Research & Development GmbH

  公开号：EP2036548A1

  公开（公告）日：2009-03-18

  The present invention relates to the use of an 11-β-HSD-type 1 and/or type 2 inhibitor for the manufacture of a pharmaceutical agent for the prevention and/or treatment of inflammation-induced and/or immune-mediated loss of bone and/or cartilage.

  本发明涉及使用 11-β-HSD 1 型和/或 2 型抑制剂制造药剂，以预防和/或治疗炎症诱导和/或免疫介导的骨和/或软骨损失。
• 11Beta -Hydroxysteroid Dehydrogenases
  申请人：Wilckens Thomas

  公开号：US20080153791A1

  公开（公告）日：2008-06-26

  The present invention relates to novel 11β-HSD inhibitors as well as to the use of 11 β-HSD inhibitors for the manufacture of pharmaceutical agents for the prevention and/or treatment of metabolic diseases, cancer, cell proliferation, glaucoma, diseases associated with abnormal growth hormone secretion as well as wound healing disorders.
• PREVENTION AND TREATMENT OF INFLAMMATION-INDUCED AND/OR IMMUNE-MEDIATED BONE LOSS
  申请人：WILCKENS Thomas

  公开号：US20110275584A1

  公开（公告）日：2011-11-10

  The present invention relates to the use of an 11-β-HSD-type 1 and/or type 2 inhibitor for the manufacture of a pharmaceutical agent for the prevention and/or treatment of inflammation-induced and/or immune-mediated loss of bone and/or cartilage.