Lilly 53857 | 60634-51-7

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 麦角林及其衍生物
• 英文名称: Lilly 53857
• 英文别名: (Z)-but-2-enedioic acid;3-hydroxybutan-2-yl (6aR,9R,10aR)-7-methyl-4-propan-2-yl-6,6a,8,9,10,10a-hexahydroindolo[4,3-fg]quinoline-9-carboxylate
• CAS: 60634-51-7
• 化学式: C27H36N2O7
• 分子量: 500.6
• InChiKey: DYJVZTAMQYDCLP-VCSAJMHUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.21
• 重原子数：
  36
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  129
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• COMBINATION PRODUCT FOR THE TREATMENT OF NEUROLOGICAL AND/OR PSYCHIATRIC DISORDERS
  申请人：Consejo Superior de Investigaciones Científicas (CSIC)

  公开号：EP3713568A1

  公开（公告）日：2020-09-30
• Manipulation of brain CDP-diacylglycerol and uses thereof
  申请人：Tyeryar Kimberly R.

  公开号：US20080039443A1

  公开（公告）日：2008-02-14

  Provided herein methods of screening for potential antidepressant compounds effective to increase production of cellular CDP-diacylglycerol and synthesis of inositol phospholipid in depression-related areas of the brain. Also, provided are methods of diagnosing and treating depressive or mood disorders in a subject by administering these screened antidepressant compounds. Further provided is a method of determining the therapeutic efficacy of an antidepressant drug regimen by comparing the ratio of CDP-diacylglycerol/inositol phosphate after treatment to a basal ratio in a subject.
• US7763603B2
  申请人：——

  公开号：US7763603B2

  公开（公告）日：2010-07-27
• US8278296B2
  申请人：——

  公开号：US8278296B2

  公开（公告）日：2012-10-02