Adviamycinon | 909085-58-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 并四苯
• 英文名称: Adviamycinon
• 英文别名: doxorubicinone；Adriamycin aglycone；6,7,9,11-tetrahydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione
• CAS: 909085-58-1
• 化学式: C₂₁H₁₈O₉
• 分子量: 414.369
• InChiKey: IBZGBXXTIGCACK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  30
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  162
• 氢给体数：
  5
• 氢受体数：
  9

文献信息

• Multifunctional Degradable Nanoparticles with Control over Size and Functionalities
  申请人：Harth Eva M.

  公开号：US20110257343A1

  公开（公告）日：2011-10-20

  In one aspect, the invention relates to polymers, crosslinked polymers, functionalized polymers, nanoparticles, and functionalized nanoparticles and methods of making and using same. In one aspect, the invention relates to degradable polymer and degradable nanoparticles. In one aspect, the invention relates to methods of preparing degradable nanoparticles and, more specifically, methods of controlling particle size during the preparation of degradable nanoparticles. In one aspect, the degradable nanoparticles are useful for complexing, delivering, and releasing payloads, including pharmaceutically active payloads. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  一方面，本发明涉及聚合物、交联聚合物、功能化聚合物、纳米颗粒和功能化纳米颗粒的制备和使用方法。另一方面，本发明涉及可降解聚合物和可降解纳米颗粒。另一方面，本发明涉及制备可降解纳米颗粒的方法，更具体地说，涉及在制备可降解纳米颗粒过程中控制颗粒大小的方法。另一方面，可降解纳米颗粒可用于复合、传递和释放药物活性载荷等用途。本摘要旨在作为搜索特定领域的扫描工具，不限制本发明。
• PREPARATION AND USE OF IMMUNOSTIMULATORY COUPLING COMPLEX WHICH IS DELIVERED AND ACTIVATED IN TARGETED MANNER
  申请人：Yafei Shanghai Biolog Medicine Science & Technology Co., Ltd.

  公开号：EP4108675A1

  公开（公告）日：2022-12-28

  The present disclosure provides for the preparation and use of immunostimulatory conjugate complexes for targeted delivery and activation. In particular, the present disclosure provides compounds represented by the formula MI-S-C-A for use as linker, and drug-linked pharmaceutical compounds represented by the formula MI-S-C-A-D. The pharmaceutical compounds of the present disclosure have improved water solubility, reduced cytotoxicity, and enhanced pharmaceutical activity.

  本公开提供了免疫刺激偶联物复合物的制备和使用，以进行靶向传递和激活。特别地，本公开提供了由公式MI-S-C-A表示的化合物作为连接剂，以及由公式MI-S-C-A-D表示的药物偶联制剂。本公开的药物化合物具有改善的水溶性，降低的细胞毒性和增强的药物活性。
• Drug Transport and Delivery System
  申请人：Ghanem Elias Ghanem

  公开号：US20070265212A1

  公开（公告）日：2007-11-15

  Described are tripeptides or tetrapeptides comprising a proteolytic enzyme cleavable amiino acid moiety as a drug or pharmacologically active site or pharmacologically active group binding, transport by blood cells and delivery system as well as to the transport and delivery system coupled drugs. Such transport and delivery system is especially favorable for the treatment of diseases that lead to an enhanced activity of proteolytic enzymes such as cancer, arthritis, or are blood cell related.