N1,N12-Diacetylspermine | 61345-83-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 甲亚胺酸及其衍生物
• 英文名称: N1,N12-Diacetylspermine
• 英文别名: N-[3-[4-(3-acetamidopropylamino)butylamino]propyl]acetamide
• CAS: 61345-83-3
• 化学式: C₁₄H₃₀N₄O₂
• 分子量: 286.41
• InChiKey: NPDTUDWGJMBVEP-UHFFFAOYSA-N

物化性质

• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  20
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  82.3
• 氢给体数：
  4
• 氢受体数：
  4

安全信息

• WGK Germany：
  3

文献信息

• Polysaccharide-polyamine copolymer and use thereof in reducing uric acid concentration in plasma
  申请人：Yang Dazhi

  公开号：US10639325B2

  公开（公告）日：2020-05-05

  Disclosed is a pharmaceutical composition for treating hyperuricemia (HUA). The pharmaceutical composition includes a polysaccharide-polyamine copolymer and a pharmaceutically acceptable salt thereof as active ingredients. The polysaccharide-polyamine copolymer is formed by copolymerization of the following two parts: a selectively oxidized polysaccharide with 2,3-dialdehydo, and a polyamine with an amino functional group; the polyamine with an amino functional group and the selectively oxidized polysaccharide with 2,3-dialdehydo can form a net structure by means of covalent crosslinking, resulting in a hydrogel with an amino functional group or a granular polysaccharide-polyamine copolymer, wherein the amino functional group in the hydrogel with an amino functional group or the granular polysaccharide-polyamine copolymer can be protonated so as to form a cationic copolymer of a three-dimensional network structure having a protonated site, and the nitrogen content of the cationic copolymer and the nitrogen content of the polysaccharide-polyamine copolymer are above 12.3 wt %, and both the cationic copolymer and the polysaccharide-polyamine copolymer are water-insoluble.

  本发明公开了一种用于治疗高尿酸血症（HUA）的药物组合物。该药物组合物包括作为活性成分的多糖-多胺共聚物及其药学上可接受的盐。多糖-多胺共聚物由以下两部分共聚而成：带有 2,3-二醛的选择性氧化多糖和带有氨基官能团的多胺；具有氨基官能团的多胺和具有 2,3-二脱氢的选择性氧化多糖可通过共价交联形成网状结构，从而形成具有氨基官能团的水凝胶或颗粒状多糖-多胺共聚物、其中，具有氨基官能团的水凝胶或颗粒状多糖-多胺共聚物中的氨基官能团可被质子化，从而形成具有质子化位点的三维网络结构的阳离子共聚物，且阳离子共聚物的氮含量和多糖-多胺共聚物的氮含量均高于 12.3 wt %，阳离子共聚物和多糖-多胺共聚物均不溶于水。
• Microcarriers, matrices and scaffolds for culturing mammalian cells and methods of manufacture
  申请人：HOWARD UNIVERSITY

  公开号：US10723809B2

  公开（公告）日：2020-07-28

  Microcarriers, matrices and scaffolds for growing mammalian cells are provided which include copolymer particles and matrices comprising of polysaccharide-polyamine copolymers. The copolymeric particles and matrices have a pore size of at least 50 microns and permit the mammalian cells to grow both on an exterior surface of the particles and matrices and within an interior of the particles and matrices. Methods for making such microcarriers, matrices and scaffolds, and compositions are also provided. Methods for growing mammalian cells utilizing such microcarriers, matrices and scaffolds and compositions are also provided.

  本发明提供了用于生长哺乳动物细胞的微载体、基质和支架，其中包括由多糖-多胺共聚物组成的共聚物颗粒和基质。这些共聚物颗粒和基质的孔径至少为 50 微米，可使哺乳动物细胞在颗粒和基质的外表面以及颗粒和基质的内部生长。此外，还提供了制造这种微载体、基质和支架以及组合物的方法。还提供了利用这种微载体、基质和支架及组合物生长哺乳动物细胞的方法。
• Polysaccharide-polyamine copolymers for removal of phosphate
  申请人：HOWARD UNIVERSITY

  公开号：US10849927B2

  公开（公告）日：2020-12-01

  Covalently cross-linked copolymers are described herein. More specifically, polysaccharide-polyamine copolymeric matrices or structures and cationic copolymeric matrices are described herein. The polysaccharide-polyamine copolymers, when protonated, can form cationic copolymeric matrices having exceptionally high densities of cationic sites. In one form, the covalently cross-linked copolymers provide a three-dimensional structure, especially when hydrated.

  本文介绍了共价交联共聚物。更具体地说，本文介绍了多糖-多胺共聚物基质或结构以及阳离子共聚物基质。多糖-多胺共聚物质子化后可形成阳离子共聚物基质，其阳离子位点密度极高。其中一种形式的共价交联共聚物具有三维结构，特别是在水合时。
• POLYSACCHARIDE-POLYAMINE COPOLYMER AND USE THEREOF IN REDUCING LOW DENSITY LIPOLIPOPROTEIN (LDL) CONCENTRATION IN PLASMA
  申请人：YANG Dazhi

  公开号：US20180071331A1

  公开（公告）日：2018-03-15

  Disclosed is a pharmaceutical composition for treating hypercholesterolemia. The pharmaceutical composition includes a polysaccharide-polyamine copolymer and a pharmaceutically acceptable salt thereof as active ingredients. The polysaccharide-polyamine copolymer is formed by copolymerization of the following two parts: a selectively oxidized polysaccharide with 2,3-dialdehyde, and a polyamine with an amino functional group; the polyamine with an amino functional group and the selectively oxidized polysaccharide with 2,3-dialdehyde can form a net structure by means of covalent crosslinking, resulting in a hydrogel with an amino functional group or a granular polysaccharide-polyamine copolymer, wherein the amino functional group in the hydrogel with an amino functional group or the granular polysaccharide-polyamine copolymer can be protonated so as to form a cationic copolymer of a three-dimensional network structure having a protonated site, and the nitrogen content of the cationic copolymer and the nitrogen content of the polysaccharide-polyamine copolymer are above 12.3 wt %, and both the cationic copolymer and the polysaccharide-polyamine copolymer are water-insoluble.
• Polysaccharide-Polyamine Copolymers For Removal Of Phosphate
  申请人：Howard University

  公开号：US20180099007A1

  公开（公告）日：2018-04-12

  Covalently cross-linked copolymers are described herein. More specifically, polysaccharide-polyamine copolymeric matrices or structures and cationic copolymeric matrices are described herein. The polysaccharide-polyamine copolymers, when protonated, can form cationic copolymeric matrices having exceptionally high densities of cationic sites. In one form, the covalently cross-linked copolymers provide a three-dimensional structure, especially when hydrated.