cochlearol X

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并吡喃类
• 英文名称: cochlearol X
• 英文别名: 2,6a-Dihydroxy-6,6-dimethyl-7,8-dihydrobenzo[c]chromen-9-one；2,6a-dihydroxy-6,6-dimethyl-7,8-dihydrobenzo[c]chromen-9-one
• 化学式: C₁₅H₁₆O₄
• 分子量: 260.29
• InChiKey: SCJKEDSTONEJPI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  19
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  cochlearol X 生成 cochlearol X 、 cochlearol X
  参考文献：
  名称：

  Renoprotective phenolic meroterpenoids from the mushroom Ganoderma cochlear

  摘要：

  Twelve previously undescribed phenolic meroterpenoids, cochlearols N-Y, along with two known analogs, ganocochlearins B and C, were isolated from the fruiting bodies of Ganoderma cochlear. Most of these substances were isolated as racemic mixtures. The structures of cochlearols N-Y were assigned based upon spectroscopic data and theoretical calculations. The renoprotective activities of these compounds were evaluated using normal and diseased rat renal interstitial fibroblast cells (NRK-49F). The results show that ganocochlearins S, U, X and Y display potent inhibitory activities against fibronectin overproduction in TGF-beta 1-induced NRK-49F cells.

  DOI：

  10.1016/j.phytochem.2019.03.019