4H-萘-1,3-二酮 | 105801-86-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 4H-萘-1,3-二酮
• 英文名称: 2,4-dioxo-1,2,3,4-tetrahydronaphthalene
• 英文别名: 2,4-dioxo-3,4-dihydro-1H-naphthalene；oxo-3,4-dihydro-1H-naphthalen-1-one；naphthalene-1,3(2H)-dione；1,3-naphthalenequinone；2,4-naphthalenequinone；naphthalene-1,3-dione；naphthalen-2,4-dione；1,3-naphthoquinone；3-naphthoquinone；Naphthalene-1,3(2H,4H)-dione；4H-naphthalene-1,3-dione
• CAS: 105801-86-3
• 化学式: C₁₀H₈O₂
• 分子量: 160.172
• InChiKey: KXXLCMPSLFIEEH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4H-萘-1,3-二酮 、 2,3-Diphenylindolizin-4-ium-1-one;triiodide 在 吡啶 作用下， 反应 1.0h， 以89%的产率得到2-[1-Oxo-2,3-diphenyl-1H-indolizin-(7E)-ylidene]-4H-naphthalene-1,3-dione
  参考文献：
  名称：

  Indolizines. 4. Dyes derived from oxoindolizinium ions and active methylene compounds

  摘要：

  DOI：

  10.1021/jo00276a029

文献信息

• [EN] STAT3 INHIBITORS AND THEIR ANTICANCER USE<br/>[FR] INHIBITEURS DE STAT3 ET LEUR UTILISATION ANTICANCÉREUSE
  申请人：OHIO STATE INNOVATION FOUNDATION

  公开号：WO2014028909A1

  公开（公告）日：2014-02-20

  In one aspect, the invention relates to substituted substituted 6-amino-5,8-dioxo-5,8- dihydronaphthalene- 1 -sulfonamide analogs and derivatives thereof, substituted 4-amino-5H- naphtho[l,8-cd]isothiazol-5-one 1,1-dioxide analogs and derivatives thereof, and related compounds, which are useful as inhibitors of STAT protein activity; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders of uncontrolled cellular proliferation associated with a STAT protein activity dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  在一个方面，该发明涉及替代的替代6-氨基-5,8-二氧化-5,8-二氢萘磺酰胺类似物及其衍生物，替代的4-氨基-5H-萘并[1,8-cd]异噻唑酮-5-酮1,1-二氧化物类似物及其衍生物，以及相关化合物，这些化合物可用作STAT蛋白活性的抑制剂；制备这些化合物的合成方法；包含这些化合物的药物组合物；以及使用这些化合物和组合物治疗与STAT蛋白活性功能障碍相关的细胞不受控制增殖的疾病的方法。本摘要旨在作为在特定领域进行搜索的扫描工具，并不旨在限制本发明。
• Microwave assisted combinatorial chemistry synthesis of substituted pyridines
  作者：Ian C. Cotterill、Alexander Ya. Usyatinsky、John M. Arnold、Douglas S. Clark、Jonathan S. Dordick、Peter C. Michels、Yuri L. Khmelnitsky

  DOI：10.1016/s0040-4039(97)10796-1

  日期：1998.3

  (Microwave-assisted Combinatorial Synthesis) for generating combinatorial libraries is described. The technology is applied to the high throughput, automated, one-step, parallel synthesis of diverse substituted pyridines using the Hantzsch synthesis. The advantages of microwave-assisted chemistry for combinatorial synthesis include a broad range of available chemistries, simple reaction setup and product

  描述了一种用于生成组合库的新型高效MICROCOS技术（微波辅助组合合成）。该技术已应用于使用Hantzsch合成技术的高通量，自动化，一步一步，多种取代吡啶的并行合成中。微波辅助化学用于组合合成的优点包括广泛的可用化学方法，简单的反应设置和易于自动化的产物回收，极短的反应时间以及高产物收率。
• [EN] AMINO-QUINONE ANTIPOLYMERANTS AND METHODS OF USING<br/>[FR] AGENT D'ANTIPOLYMÉRISATION À BASE D'AMINO-QUINONE ET PROCÉDÉS D'UTILISATION
  申请人：ECOLAB USA INC

  公开号：WO2020068735A1

  公开（公告）日：2020-04-02

  Described are methods and composition for inhibiting polymerization of a monomer (e.g., styrene) composition using an aminated quinone antipolymerant, such as an aminated benzoquinone or aminated naphthoquinone antipolymerant having one or more secondary or tertiary amine group(s). The aminated quinone antipolymerant can be used with little or no nitroxyl group containing antipolymerant yet still provide excellent antipolymerant activity in a monomer-containing composition.

  描述了一种使用氨基喹诺烷抗聚合剂（例如，氨基苯醌或氨基萘醌抗聚合剂）来抑制单体（例如苯乙烯）组合物的聚合的方法和组合物，该氨基喹诺烷抗聚合剂具有一个或多个次级或三级胺基团。氨基喹诺烷抗聚合剂可以与几乎不含氮氧自由基的抗聚合剂一起使用，但仍然在含单体组合物中提供出色的抗聚合活性。
• OLEFIN-DIENE COPOLYMER AND PROCESS FOR PRODUCING THE SAME
  申请人：Osakada Kohtaro

  公开号：US20080214755A1

  公开（公告）日：2008-09-04

  A copolymer containing units represented by the defined formula (1) and olefin units; and a process for producing the copolymer, which comprises the step of copolymerizing a compound represented by the defined formula (3) with an olefin, the units represented by the formula (1) being polymerized units of the compound represented by the formula (3) such as 5,5-diallyl-2,2-dimethyl-1,3-dioxane.

  一种共聚物，包含由定义公式(1)和烯烃单位表示的单元;以及一种生产该共聚物的方法，其中包括将由定义公式(3)表示的化合物与烯烃共聚的步骤，由公式(1)表示的单元是由公式(3)表示的化合物的聚合单元，例如5,5-二烯基-2,2-二甲基-1,3-二噁烷。
• STAT3 INHIBITORS AND THEIR ANTICANCER USE
  申请人：Ohio State Innovation Foundation

  公开号：US20150232434A1

  公开（公告）日：2015-08-20

  In one aspect, the invention relates to substituted 6-amino-5,8-dioxo-5,8-dihydronaphthalene-1-sulfonamide analogs and derivatives thereof, substituted 4-amino-5H-naphtho[1,8-cd]isothiazol-5-one 1,1-dioxide analogs and derivatives thereof, and related compounds, which are useful as inhibitors of STAT protein activity; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders of uncontrolled cellular proliferation associated with a STAT protein activity dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  本发明涉及替代的6-氨基-5,8-二氧代-5,8-二氢萘酚-1-磺酰胺类似物及其衍生物，替代的4-氨基-5H-萘并[1,8-cd]异噻唑-5-酮1,1-二氧化物类似物及其衍生物以及相关化合物，它们可用作STAT蛋白活性的抑制剂；制备这些化合物的合成方法；包含这些化合物的制药组合物；以及使用这些化合物和组合物治疗与STAT蛋白活性功能障碍相关的细胞不受控制增殖紊乱的方法。本摘要旨在作为特定领域搜索的工具，不限制本发明。