cudraxanthone Q

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: cudraxanthone Q
• 英文别名: brasixanthone B；5,8-dihydroxy-2,2-dimethyl-12-(3-methylbut-2-enyl)pyrano[3,2-b]xanthen-6-one
• 化学式: C₂₃H₂₂O₅
• 分子量: 378.425
• InChiKey: BFPCRQCNDMJVOT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  28
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  cudraxanthone Q 在 吡啶 、 氧气 、 hematoporphyrin 作用下， 反应 0.67h， 以21%的产率得到12-(2-Hydroperoxy-3-methyl-but-3-enyl)-5,8-dihydroxy-2,2-dimethyl-2H-pyrano[3,2-b]xanthen-6-one
  参考文献：
  名称：

  Chemical Constituents of Calophyllum brasiliensis:  Structure Elucidation of Seven New Xanthones and Their Cancer Chemopreventive Activity

  摘要：

  The first study of chemical constituents of the stem bark of Calophyllum brasilienses collected in Brazil has led to the isolation and identification of seven new xanthones named brasixanthones A (1), B (4), C (5), D (6), E (2), F (3), and G (10), together with 10 known xanthones. Among the xanthones isolated in this study, 4, 5, 6, and 11 were found to exhibit significant inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate induced Epstein-Barr virus early antigen activation in Raji cells.

  DOI：

  10.1021/np010398s

文献信息

• Chemical Constituents of <i>Calophyllum </i><i>b</i><i>rasiliensis</i>:  Structure Elucidation of Seven New Xanthones and Their Cancer Chemopreventive Activity
  作者：Chihiro Ito、Masataka Itoigawa、Yoshitaka Mishina、Valdir Cechinel Filho、Teruo Mukainaka、Harukuni Tokuda、Hoyoku Nishino、Hiroshi Furukawa

  DOI：10.1021/np010398s

  日期：2002.3.1

  The first study of chemical constituents of the stem bark of Calophyllum brasilienses collected in Brazil has led to the isolation and identification of seven new xanthones named brasixanthones A (1), B (4), C (5), D (6), E (2), F (3), and G (10), together with 10 known xanthones. Among the xanthones isolated in this study, 4, 5, 6, and 11 were found to exhibit significant inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate induced Epstein-Barr virus early antigen activation in Raji cells.