2,4,6,8-Tetrahydroxy-1-(3-methylbut-2-enyl)xanthen-9-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2,4,6,8-Tetrahydroxy-1-(3-methylbut-2-enyl)xanthen-9-one
• 化学式: C₁₈H₁₆O₆
• 分子量: 328.3
• InChiKey: BRERQMIMCLBRCS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  107
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• USAGE OF 1,3,5,7-TETRAHYDROXY-8-ISOPRENYLXANTHONE FOR TREATING INFLAMMATION
  申请人：Hong Kong Baptist University

  公开号：US20140200265A1

  公开（公告）日：2014-07-17

  This invention relates to the use of a natural compound from natural sources for its therapeutic uses. More particularly, it relates to a compound 1,3,5,7-tetrahydroxy-8-isoprenylxanthone (TI, FIG. 1 ), that is naturally occurring in the plant of Garcinia esculenta Y. H. Li, and its biological activity of inhibiting nitric oxide production and microRNA 155 expression in stimulated macrophages, which can be developed as potential anti-inflammatory drugs.