2,2-difluoro-N-[[(5S)-3-[3-fluoro-4-[4-[(5-nitrofuran-2-yl)methyl]piperazin-1-yl]phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide | 1026718-88-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2,2-difluoro-N-[[(5S)-3-[3-fluoro-4-[4-[(5-nitrofuran-2-yl)methyl]piperazin-1-yl]phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide
• CAS: 1026718-88-6
• 化学式: C₂₁H₂₂F₃N₅O₆
• 分子量: 497.431
• InChiKey: DWOYKRAIDUNFPN-HNNXBMFYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  35
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  124
• 氢给体数：
  1
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  (S)-N-[[3-[3-fluoro-4-[1-piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]difluoroacetamide 、 5-硝基糠醛 在 三乙酰氧基硼氢化钠 作用下， 以 四氢呋喃 为溶剂， 反应 24.75h， 以0.1 g的产率得到2,2-difluoro-N-[[(5S)-3-[3-fluoro-4-[4-[(5-nitrofuran-2-yl)methyl]piperazin-1-yl]phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide
  参考文献：
  名称：

  Synthesis and biological activity of novel oxazolidinones

  摘要：

  A number of 5-substituted derivatives of Ranbezolid, a novel oxazolidinone were synthesized. Antibacterial activity of the compounds against a number of sensitive and resistant bacteria showed promising results. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.09.054

文献信息

• Synthesis and biological activity of novel oxazolidinones
  作者：Biswajit Das、A.V.S. Rajarao、Sonali Rudra、Ajay Yadav、Abhijit Ray、Manisha Pandya、Ashok Rattan、Anita Mehta

  DOI：10.1016/j.bmcl.2009.09.054

  日期：2009.11

  A number of 5-substituted derivatives of Ranbezolid, a novel oxazolidinone were synthesized. Antibacterial activity of the compounds against a number of sensitive and resistant bacteria showed promising results. (C) 2009 Elsevier Ltd. All rights reserved.