5'alpha-苄基-12'-羟基-2'-甲基麦角它曼-3',6',18-三酮马来酸盐 | 61498-90-6

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 麦角林及其衍生物
• 中文名称: 5'alpha-苄基-12'-羟基-2'-甲基麦角它曼-3',6',18-三酮马来酸盐
• 英文名称: 5'alpha-Benzyl-12'-hydroxy-2'-methylergotaman-3',6',18-trione maleate
• 英文别名: (6aR,9R)-N-[(1S,2S,4R,7S)-7-benzyl-2-hydroxy-4-methyl-5,8-dioxo-3-oxa-6,9-diazatricyclo[7.3.0.02,6]dodecan-4-yl]-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide;(Z)-but-2-enedioic acid
• CAS: 61498-90-6
• 化学式: C37H39N5O9
• 分子量: 697.7
• InChiKey: FODBCFCRBVHWSZ-UNMUSCHYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  51
• 可旋转键数：
  6
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  193
• 氢给体数：
  5
• 氢受体数：
  10

文献信息

• ADHESIVE PATCH
  申请人：HISAMITSU PHARMACEUTICAL CO., INC.

  公开号：EP1541177A1

  公开（公告）日：2005-06-15

  A patch comprising a backing layer and an adhesive layer disposed on the backing layer and compounded with a drug and an adhesive base agent, wherein the adhesive base agent comprises styreneisoprene-styrene block copolymer, 2-ethylhexyl acrylate - vinyl acetate copolymer and a basic nitrogen-including polymer including a basic nitrogen and having no adhesion property at normal temperature.

  一种贴片，包括背衬层和设置在背衬层上的粘合剂层，并与药物和粘合剂基剂复合，其中粘合剂基剂包括苯乙烯异戊二烯-苯乙烯嵌段共聚物、丙烯酸 2-乙基己酯-醋酸乙烯酯共聚物和包括碱性氮的聚合物，且在常温下无粘合性。
• Compositions of pharmaceutical actives containing diethylene glycol monoethyl ether or other alkyl derivatives
  申请人：THEMIS MEDICARE LIMITED

  公开号：US10940205B2

  公开（公告）日：2021-03-09

  The present invention relates to pharmaceutical compositions of various pharmaceutical actives, especially lyophilic and hydrophilic actives containing Diethylene glycol monoethyl ether or other alkyl derivatives thereof as a primary vehicle and/or to pharmaceutical compositions utilizing Diethylene glycol monoethyl ether or other alkyl derivatives thereof as a primary vehicle or as a solvent system in preparation of such pharmaceutical compositions. The pharmaceutical compositions of the present invention are safe, non-toxic, exhibits enhanced physical stability compared to conventional formulations containing such pharmaceutical actives and are suitable for use as injectables for intravenous and intramuscular administration, as well as for use as a preformed solution/liquid for filling in and preparation of capsules, tablets, nasal sprays, gargles, dermal applications, gels, topicals, liquid oral dosage forms and other dosage forms.

  本发明涉及各种药物活性物质的药物组合物，特别是含有二乙二醇单乙醚或其 他烷基衍生物作为主要载体的冻干和亲水活性物质，和/或涉及利用二乙二醇单乙醚或其 他烷基衍生物作为主要载体或作为制备此类药物组合物的溶剂系统的药物组合物。本发明的药物组合物安全、无毒，与含有此类药物活性成分的传统制剂相比，具有更强的物理稳定性，适合用作静脉注射和肌肉注射的注射剂，也适合用作预制溶液/液体，用于填充和制备胶囊、片剂、鼻腔喷雾剂、漱口水、皮肤应用、凝胶、外用药、口服液剂型和其他剂型。
• Adhesive patch
  申请人：Terahara Takaaki

  公开号：US20050260255A1

  公开（公告）日：2005-11-24

  A patch comprising a backing layer and an adhesive layer disposed on the backing layer and compounded with a drug and an adhesive base agent, wherein the adhesive base agent comprises styrene-isoprene-styrene block copolymer, 2-ethylhexyl acrylate—vinyl acetate copolymer and a basic nitrogen-including polymer including a basic nitrogen and having no adhesion property at normal temperature.
• COMPOSITIONS OF PHARMACEUTICAL ACTIVES CONTAINING DIETHYLENE GLYCOL MONOETHYL ETHER OR OTHER ALKYL DERIVATIVES
  申请人：THEMIS MEDICARE LIMITED

  公开号：US20140296191A1

  公开（公告）日：2014-10-02

  The present invention relates to pharmaceutical compositions of various pharmaceutical actives, especially lyophilic and hydrophilic actives containing Diethylene glycol monoethyl ether or other alkyl derivatives thereof as a primary vehicle and/or to pharmaceutical compositions utilizing Diethylene glycol monoethyl ether or other alkyl derivatives thereof as a primary vehicle or as a solvent system in preparation of such pharmaceutical compositions. The pharmaceutical compositions of the present invention are safe, non-toxic, exhibits enhanced physical stability compared to conventional formulations containing such pharmaceutical actives and are suitable for use as injectables for intravenous and intramuscular administration, as well as for use as a preformed solution/liquid for filling in and preparation of capsules, tablets, nasal sprays, gargles, dermal applications, gels, topicals, liquid oral dosage forms and other dosage forms.
• US9827315B2
  申请人：——

  公开号：US9827315B2

  公开（公告）日：2017-11-28