salvianolic acid L

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: salvianolic acid L
• 英文别名: 2-[3-[1-carboxy-2-(3,4-dihydroxyphenyl)ethoxy]carbonyl-2-(3,4-dihydroxyphenyl)-7,8-dihydroxy-1,2-dihydronaphthalene-1-carbonyl]oxy-3-(3,4-dihydroxyphenyl)propanoic acid
• 化学式: C₃₆H₃₀O₁₆
• 分子量: 718.625
• InChiKey: CLZDRNKNWXDFQT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  52
• 可旋转键数：
  13
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  289
• 氢给体数：
  10
• 氢受体数：
  16

反应信息

• 作为反应物：
  描述：

  salvianolic acid L 在 盐酸 作用下， 反应 2.0h， 以80%的产率得到7,8-dihydroxy-2-(3,4-dihydroxyphenyl)-1,2-dihydronaphthalene-1,3-dicarboxylic acid 3-(1-carboxy-2-(3,4-dihydroxyphenyl))ethyl ester
  参考文献：
  名称：

  Salvianolic acid L, a potent phenolic antioxidant from Salvia officinalis

  摘要：

  Salvianolic acid L. a rosmarinic acid dimer, was isolated from Salvia officinalis and identified as 7,8-dihydroxy-2-(3,4-dihydroxyphenyl)-1,2-dihydronaphthatene-1,3-dicarboxylic acid di(1-carboxy-2-(3,4-dihydroxyphenyl))ethyl ester. Two novel hydrolytic products 7,8-dihydroxy-2-(3,4-dihydroxyphenyl)-1,2-dihydronaphthalene-1,3-dicarboxylic acid and the corresponding 3-monoester were also isolated and characterized. Salvianolic acid L showed strong free radical scavenging activities for DPPH and superoxide anion radicals. (C) 2001 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(01)01738-5

文献信息

• COMPOSITIONS AND METHODS FOR TREATING INFLAMMATION AND INFLAMMATION-RELATED DISORDERS BY PLECTRANTHUS AMBOINICUS EXTRACTS
  申请人：Wong Chi-Huey

  公开号：US20090076143A1

  公开（公告）日：2009-03-19

  The crude extract of Plectranthus Amboinicus (PA) has anti-inflammatory effects and can inhibit AP-1 binding in vitro. The incubation with PA crude extract resulted in significant inhibition of the LPS-induced expression of IL-6, IL-12, MCP-1, and RANTES in HUVEC cells. After the crude extract was further fractionated using preparative HPLC, fraction 8, 9, 10 and 11 were identified to inhibit the AP-1 binding activity. The active component of fraction 8 is Mena 987; fraction 9 is Mena 998; fraction 10 is Mena 9102; and fraction 11 is rosmarinic acid and the synthestic rosmarinic acid analogues. Other compounds showed inhibitory activities as well. These compounds have inhibitory effects on AP-1 activity and are useful as preventive or therapeutic agent for diseases in which excessive expression or activities of AP-1 are involved.
• US8105636B2
  申请人：——

  公开号：US8105636B2

  公开（公告）日：2012-01-31
• Salvianolic acid L, a potent phenolic antioxidant from Salvia officinalis
  作者：Yinrong Lu、L.Yeap Foo

  DOI：10.1016/s0040-4039(01)01738-5

  日期：2001.11

  Salvianolic acid L. a rosmarinic acid dimer, was isolated from Salvia officinalis and identified as 7,8-dihydroxy-2-(3,4-dihydroxyphenyl)-1,2-dihydronaphthatene-1,3-dicarboxylic acid di(1-carboxy-2-(3,4-dihydroxyphenyl))ethyl ester. Two novel hydrolytic products 7,8-dihydroxy-2-(3,4-dihydroxyphenyl)-1,2-dihydronaphthalene-1,3-dicarboxylic acid and the corresponding 3-monoester were also isolated and characterized. Salvianolic acid L showed strong free radical scavenging activities for DPPH and superoxide anion radicals. (C) 2001 Published by Elsevier Science Ltd.