7-(Furan-3-yl)-1,8,12,16,16-pentamethyl-3,6-dioxapentacyclo[9.8.0.02,4.02,8.012,17]nonadeca-13,17-diene-5,15,19-trione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并吡喃类
• 英文名称: 7-(Furan-3-yl)-1,8,12,16,16-pentamethyl-3,6-dioxapentacyclo[9.8.0.02,4.02,8.012,17]nonadeca-13,17-diene-5,15,19-trione
• 英文别名: 7-(furan-3-yl)-1,8,12,16,16-pentamethyl-3,6-dioxapentacyclo[9.8.0.02,4.02,8.012,17]nonadeca-13,17-diene-5,15,19-trione
• 化学式: C₂₆H₂₈O₆
• 分子量: 436.5
• InChiKey: DINLEWSRQRXQCK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  32
• 可旋转键数：
  1
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  86.1
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• [EN] DERIVATIVES OF LIMONOIDS FOR TREATING AND/OR PREVENTING GROWTH OF BREAST CANCER CELLS<br/>[FR] DÉRIVÉS DE LIMONOÏDES POUR LE TRAITEMENT ET/OU LA PRÉVENTION DE LA CROISSANCE DE CELLULES DU CANCER DU SEIN
  申请人：INSTITUT NATIONAL DE LA SANTE ET DE LA RECH MEDICALE (INSERM)

  公开号：WO2017198849A1

  公开（公告）日：2017-11-23

  The present invention relates to new compounds derivatives of limonoids for treating and/or preventing growth of cancer cells, particularly for treating the breast cancer. Breast cancer is cancer that develops from breast tissue. It is the most common invasive cancer in women. The inventors have now discovered new derivatives of type limonoid, which possess a powerful anticancer activity, with, at the same time, low toxicity. They have demonstrated that these novel derivatives are efficient against breast cancer cell lines. In particular, the present invention relates to compounds of formula (I) for use for treating the breast cancer. Particularly, the inventors tested the compounds on cell line MDA-MB-468, and in particular, the impact of the compounds on mitotic phase and on cell death in cancer cells have been analysed.