9-[2-(tert-butylamino)acetamido]-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 四环素类
• 英文名称: 9-[2-(tert-butylamino)acetamido]-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
• 化学式: C29H39N5O8
• InChiKey: FPZLLRFZJZRHSY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.51
• 重原子数：
  42.0
• 可旋转键数：
  6.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  205.76
• 氢给体数：
  7.0
• 氢受体数：
  11.0

文献信息

• METHODS OF USING SUBSTITUTED TETRACYCLINE COMPOUNDS TO MODULATE RNA
  申请人：Paratek Pharmaceuticals, Inc.

  公开号：US20150321997A1

  公开（公告）日：2015-11-12

  A method for modulating RNA with tetracycline compounds is described.

  描述了一种用四环素化合物调节RNA的方法。
• SUBSTITUTED TETRACYCLINES
  申请人：Concert Pharmaceutcals Inc.

  公开号：US20130296279A1

  公开（公告）日：2013-11-07

  The invention in one embodiment is directed to a compound of formula (I) or a pharmaceutically acceptable salt thereof. The invention is also directed to a composition comprising the compound of formula I or a pharmaceutically acceptable salt, and methods of treating the indications listed herein.