6,8-dihydroxy-2-(4-hydroxyphenyl)-4H-naphthalen-1-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 6,8-dihydroxy-2-(4-hydroxyphenyl)-4H-naphthalen-1-one
• 化学式: C₁₆H₁₂O₄
• 分子量: 268.26
• InChiKey: GMTRAJSDPMKWDN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• USE OF GLUCOSIDASE INHIBITORS FOR THERAPY OF MUCOVISIDOSIS
  申请人：BECQ Frédéric

  公开号：US20110269795A1

  公开（公告）日：2011-11-03

  A method provides for the use of glycosidase inhibitors selected from compounds of general formula (1), wherein R 1 represents a CH 3 group, or CH 2 OH, R 2 represents H or an alkyl group having 1-5 carbon atoms, or R 1 and R 2 together form a group having formula (II), with carbon in position (a) and nitrogen of formula (I) mentioned above, for the preparation of a medicament used to treat mucovisidosis. A corresponding product is also described.
• METHODS OF MAKING AND USING COMPOSITIONS COMPRISING FLAVONOIDS
  申请人：Birbara Philip J.

  公开号：US20120213842A1

  公开（公告）日：2012-08-23

  The subject invention relates to novel micoparticulate and soluble forms of flavonoids, and their synthesis. The invention also includes novel formulations of such flavonoids. Further, the invention includes novel methods of manufacturing the flavonoid formulations. The invention also relates to a wide variety of applications of the flavonoid formulations.
• POLYPHENOL/FLAVONOID COMPOSITIONS AND METHODS OF FORMULATING ORAL HYGIENIC PRODUCTS
  申请人：API Genesis, LLC

  公开号：US20140314686A1

  公开（公告）日：2014-10-23

  Microemulsions and soluble alkali metal salts of relatively insoluble aglycone polyphenols within oral hygienic products are disclosed for treating oral inflammatory disorders. The formulations can act as a bactericide or bacteriostat. The methods include the process associated with the formation of a high temperature polyphenol/surfactant concentrate, a nano-particulate precipitation process in the presence of a surfactant and the solubilization of relatively insoluble aglycone polyphenols/flavonoids by the formation of soluble alkali metal salts within alkaline oral compositions.
• NANOPARTICLE ISOFLAVONE COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME
  申请人：Humanetics Corporation

  公开号：US20210000788A1

  公开（公告）日：2021-01-07

  The present invention is directed to formulations of genistein and methods for making and using, the same. In particular embodiments, the formulations described herein include suspension formulations of nanoparticulate genistein.
• US8242136B2
  申请人：——

  公开号：US8242136B2

  公开（公告）日：2012-08-14