4-[2-(3-Hydroxyphenyl)ethyl]-2,6-dimethoxyphenol

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 4-[2-(3-Hydroxyphenyl)ethyl]-2,6-dimethoxyphenol
• 英文别名: 4-[2-(3-hydroxyphenyl)ethyl]-2,6-dimethoxyphenol
• 化学式: C₁₆H₁₈O₄
• 分子量: 274.31
• InChiKey: HJFGFCYQHBUEMB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  58.9
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Method of using dihydro-resveratrol or its stilbenoid derivatives and/or chemical variants in treatment of tumorous pathologies
  申请人：Hong Kong Baptist University

  公开号：US10017442B2

  公开（公告）日：2018-07-10

  The present invention relates to a polyphenol derivative of the stilbenoid family, namely trans-3,5,4′-trihydroxybibenzyl, also known as dihydro-resveratrol, as a remedial agent. In particular, the present invention presents the usage of dihydro-resveratrol or its derivatives/chemical variants in the manufacture of a medicament for the treatment of tumors or cancers. The dihydrostilbenes can be used in the treatment or delay of progression of a cancer in a patient or used in a pharmaceutical formulation for the aforementioned purposes.

  本发明涉及一种白藜芦醇家族的多酚衍生物，即反式-3,5,4′-三羟基白藜芦醇，又称二氢白藜芦醇，可作为一种治疗剂。特别是，本发明提出了二氢白藜芦醇或其衍生物/化学变体在制造治疗肿瘤或癌症的药物中的用途。二氢白藜芦醇可用于治疗或延缓患者的癌症进展，或用于上述目的的药物制剂中。
• Skin-protection composition containing Dendrobium-based ingredients
  申请人：Hong Kong Baptist University

  公开号：US10188590B2

  公开（公告）日：2019-01-29

  The present invention relates to a skin-protection composition that comprises stilbenoid(s) and/or stilbenoid-containing extract(s) obtained from Dendrobium plants, such as Dendrobium officinale and Dendrobium nobile for the management of melanogenesis, skin-darkening and skin-aging. More particularly, it relates to the usage of Dendrobium ingredients and stilbenoids to reduce the formation of melanin in melanocytes. It also relates to the usage of Dendrobium ingredients and stilbenoids to reduce the generation of reactive oxygen species and oxidative free radicals. This invention relates to the use Dendrobium-derived extracts or ingredients or stilbenoids in the formulation of skin-protection, skin-whitening and/or anti-skin aging products.

  本发明涉及一种皮肤保护组合物，该组合物包含从铁皮石斛植物（如Dendrobium officinale和Dendrobium nobile）中提取的类石斛素和/或含类石斛素的提取物，用于控制黑色素生成、皮肤变黑和皮肤老化。更具体地说，它涉及使用石斛成分和石斛素来减少黑色素细胞中黑色素的形成。本发明还涉及使用铁皮石斛成分和类石斛烯减少活性氧和氧化自由基的生成。本发明涉及在皮肤保护、皮肤美白和/或抗衰老产品配方中使用铁皮石斛提取物或成分或类石斛素。
• Method of using of dihydro-resveratrol or its stilbenoid derivatives and/or chemical variants as antimicrobial agents
  申请人：Hong Kong Baptist University

  公开号：US10351500B2

  公开（公告）日：2019-07-16

  The present invention relates to a composition for preventing or reducing microbial growth, particularly the growth of dermatophytic fungi, and/or aciduric and acidogenic gram-positive bacteria. More particularly, it relates to the use of trans-3,5,4′-trihydroxybibenzyl, also known as dihydro-resveratrol, or its dihydrostilbene derivatives and/or chemical variants as an anti-microbial agent. The present invention further relates to the management of dermatophytosis often caused by dermatophytic fungi and the management of dental caries often mediated by aciduric and acidogenic gram-positive Streptococci. The present invention therefore has applications in preventing, alleviating and/or treating dermatophytosis and dental caries.

  本发明涉及一种用于防止或减少微生物生长的组合物，特别是皮癣真菌和/或酸性和酸性革兰氏阳性菌的生长。更具体地说，它涉及反式-3,5,4′-三羟基白藜芦醇（又称二氢白藜芦醇）或其二氢芪衍生物和/或化学变体作为抗微生物剂的用途。本发明还涉及通常由皮真菌引起的皮癣病的治疗，以及通常由酸性和产酸性革兰氏阳性链球菌介导的龋齿的治疗。因此，本发明可用于预防、缓解和/或治疗皮癣病和龋齿。
• Method of Using dihydro-resveratrol or its stilbenoid derivatives and/or chemical variants in treatments of fibrotic and diabetic conditions
  申请人：Hong Kong Baptist University

  公开号：US20170057896A1

  公开（公告）日：2017-03-02

  A polyphenol derivative of the stilbenoid family, namely trans-3,5,4′-trihydroxybibenzyl, also known as dihydro-resveratrol, is disclosed as a remedial agent. In particular, the usage of dihydro-resveratrol as an anti-fibrotic agent in suppressing the activation of pancreatic stellate cells (PSCs) is presented. One embodiment also relates to the management of pancreatic fibrosis, which is often accompanied with chronic pancreatitis and desmoplastic reaction of pancreatic cancer. Another embodiment has applications in preventing or alleviating or treating pancreatic cancer or pancreatogenic diabetes.
• SKIN-PROTECTION COMPOSITION CONTAINING DENDROBIUM-BASED INGREDIENTS
  申请人：Hong Kong Baptist University

  公开号：US20170057906A1

  公开（公告）日：2017-03-02

  A skin-protection composition is shown that comprises stilbenoid(s) and/or stilbenoid-containing extract(s) obtained from Dendrobium plants, such as Dendrobium officinale and Dendrobium nobile for the management of melanogenesis, skin-darkening and skin-aging. More particularly, the usage of Dendrobium ingredients and stilbenoids is shown to reduce the formation of melanin in melanocytes. The usage of Dendrobium ingredients and stilbenoids is also shown to reduce the generation of reactive oxygen species and oxidative free radicals. The use of Dendrobium -derived extracts or ingredients or stilbenoids is shown in the formulation of skin-protection, skin-whitening and/or anti-skin aging products.