3-(Chloro-difluoro-methyl)-benzo[f]chromen-1-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并吡喃类
• 英文名称: 3-(Chloro-difluoro-methyl)-benzo[f]chromen-1-one
• 英文别名: 3-[Chloro(difluoro)methyl]benzo[f]chromen-1-one
• 化学式: C₁₄H₇ClF₂O₂
• 分子量: 280.658
• InChiKey: HJTUSHDQUOYLKV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (Z)-4-Chloro-4,4-difluoro-3-(naphthalen-2-yloxy)-but-2-enoic acid ethyl ester 在 PPA 作用下， 反应 10.0h， 生成 3-(Chloro-difluoro-methyl)-benzo[f]chromen-1-one
  参考文献：
  名称：

  A facile synthesis of fluoroalkylated chromones and their analogues from 2,2-dihydropolyfluoroalkanoates

  摘要：

  Fluoroalkylated chromones and their analogues have been prepared in good yield by the Michael addition reactions of 2,2-dihydropolyfluoroalkanoates with phenols in the presence of triethylamine, followed by acid-catalyzed intramolecular ring-closure.

  DOI：

  10.1016/0022-1139(93)02913-y

文献信息

• A facile synthesis of fluoroalkylated chromones and their analogues from 2,2-dihydropolyfluoroalkanoates
  作者：Wei-Yuan Huang、Yan-Song Liu、Long Lu

  DOI：10.1016/0022-1139(93)02913-y

  日期：1994.3

  Fluoroalkylated chromones and their analogues have been prepared in good yield by the Michael addition reactions of 2,2-dihydropolyfluoroalkanoates with phenols in the presence of triethylamine, followed by acid-catalyzed intramolecular ring-closure.