2,3,23,23,25,25-Hexamethyl-8-prop-1-en-2-yl-7,24-dioxa-31-azaoctacyclo[15.14.0.02,15.03,12.06,11.018,30.020,28.022,27]hentriaconta-1(17),10,18(30),19,26,28-hexaene-9,12-diol | 73561-91-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并吡喃类
• 英文名称: 2,3,23,23,25,25-Hexamethyl-8-prop-1-en-2-yl-7,24-dioxa-31-azaoctacyclo[15.14.0.02,15.03,12.06,11.018,30.020,28.022,27]hentriaconta-1(17),10,18(30),19,26,28-hexaene-9,12-diol
• CAS: 73561-91-8
• 化学式: C₃₇H₄₇NO₄
• 分子量: 569.8
• InChiKey: HVLXXQDJGPKVMK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  42
• 可旋转键数：
  1
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  74.7
• 氢给体数：
  3
• 氢受体数：
  4

ADMET

毒理性

• 毒性总结

震颤素类真菌毒素通过干扰神经递质的释放来发挥其毒性作用，可能是通过导致神经末梢的变性。它们被认为可以抑制γ-氨基丁酸（GABA）受体，包括突触前和突触后的，同时还能抑制GABA-T受体上的递质分解。这最初会增加神经递质的水平，增强GABA诱导的氯离子电流，然后导致突触中神经递质水平的降低。

Tremorgenic mycotoxins exert their toxic effects by interfering with neurotransmitter release, possibly by causing degeneration of nerve terminals. They are thought to inhibit gamma-aminobutyric acid (GABA) receptors, both pre- and postsynaptic, as well as inhibit transmitter breakdown at the GABA-T receptors. This would initially increase neurotransmitter levels, potentiating the GABA-induced chloride current, then lead to decreased levels of neurotransmitter in the synapse. (A2976)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 致癌物分类

对人类无致癌性（未列入国际癌症研究机构IARC清单）。

No indication of carcinogenicity to humans (not listed by IARC).

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 健康影响

震颤原真菌毒素影响中枢神经系统活动。它们会导致牛患有一种被称为“蹒跚综合症”的神经疾病。

Tremorgenic mycotoxins affect central nervous system activity. They cause a neurological disease of cattle known as "staggers syndrome". (A2976)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 暴露途径

口服、皮肤、吸入和 parenteral（被污染的药物）。 (A3101)

Oral, dermal, inhalation, and parenteral (contaminated drugs). (A3101)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 症状

震颤素类真菌毒素影响中枢神经系统活动，引起包括精神混乱、瘫痪、震颤、惊厥和死亡在内的神经症状。它们会导致牛患有一种称为“摇摆综合症”的神经疾病，其特征是肌肉震颤、过度兴奋、惊厥和共济失调。

Tremorgenic mycotoxins affect central nervous system activity, inducing neurologic symptoms including mental confusion, paralysis, tremors, seizures, and death. They cause a neurological disease of cattle known as "staggers syndrome", which is characterized by muscle tremors, hyperexcitability, convulsions and ataxia. (A2976)

来源:Toxin and Toxin Target Database (T3DB)