Tetrahydrocannabivarinic Acid (CRM)

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: Tetrahydrocannabivarinic Acid (CRM)
• 英文别名: 1-hydroxy-6,6,9-trimethyl-3-propyl-6a,7,8,10a-tetrahydrobenzo[c]chromene-2-carboxylic acid
• 化学式: C₂₀H₂₆O₄
• 分子量: 330.4
• InChiKey: IQSYWEWTWDEVNO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• BIOENZYMATIC SYNTHESIS OF THC-v, CBV AND CBN AND THEIR USE AS THERAPEUTIC AGENTS
  申请人：Full Spectrum Laboratories Ltd

  公开号：US20170283837A1

  公开（公告）日：2017-10-05

  The present invention provides methods for producing cannabinoids. More specifically, the invention is directed to the bio-enzymatic synthesis of THC-v, CBV and CBN by contacting a compound according to Formula I with a cannabinoid synthase enzyme. Also described is a system for producing these pharmaceutically important cannabinoids and the use of such cannabinoids as therapeutic agents.

  本发明提供了生产大麻素的方法。更具体地说，该发明涉及通过将符合式I的化合物与大麻素合成酶接触来生物酶合成THC-v、CBV和CBN。还描述了一种生产这些在药用上重要的大麻素的系统，以及将这些大麻素用作治疗剂的用途。
• Prenyltransferase variants with increased thermostability
  申请人：INVIZYNE TECHNOLOGIES, INC.

  公开号：US11518983B1

  公开（公告）日：2022-12-06

  The present disclosure relates to recombinant prenyltransferase enzymes with increased thermostability and activity and the use of these enzymes in compositions and methods for biosynthesis involving prenylation reactions, including compositions and methods for the preparation of cannabinoids.

  本公开涉及具有更高热稳定性和活性的重组炔基转移酶，以及这些酶在涉及炔基 化反应的生物合成的组合物和方法中的用途，包括制备大麻素的组合物和方法。
• OLIVETOL SYNTHASE VARIANTS AND METHODS FOR PRODUCTION OF OLIVETOLIC ACID AND ITS ANALOG COMPOUNDS
  申请人：Genomatica, Inc.

  公开号：EP3956462A1

  公开（公告）日：2022-02-23
• CHICORY PRODUCTS CONTAINING CANNABINOIDS
  申请人：Full Spectrum Laboratories Ltd

  公开号：US20180092392A1

  公开（公告）日：2018-04-05

  This disclosure relates to methods for making a composition of a cannabinoid and chicory flour. According to a method, the composition is manufactured by combining an amount of a cannabinoid and an amount of chicory flour comprising about 10% (w/w) to about 90% (w/w) less 11β,13-dihydrolactucin than a chicory flour made from the taproots of Cichorium intybus.
• RECOMBINANT ACYL ACTIVATING ENZYME (AAE) GENES FOR ENHANCED BIOSYNTHESIS OF CANNABINOIDS AND CANNABINOID PRECURSORS
  申请人：Willow Biosciences, Inc.

  公开号：US20220186231A1

  公开（公告）日：2022-06-16

  The present disclosure provides recombinant host cells comprising a pathway capable of producing a cannabinoid and/or cannabinoid precursor, wherein the pathway comprises an enzyme AAE from a source organism other than Cannabis sativa , such as Humulus lupulus . The disclosure also provides methods of using the host cells to produce rare cannabinoids and/or rare cannabinoid precursors.