2-acetyl-4-amino-3,10,11,12a-tetrahydroxy-6,9-dimethyl-4a,5-dihydro-4H-tetracene-1,12-dione

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-acetyl-4-amino-3,10,11,12a-tetrahydroxy-6,9-dimethyl-4a,5-dihydro-4H-tetracene-1,12-dione
• 化学式: C₂₂H₂₁NO₇
• 分子量: 411.4
• InChiKey: IRCLZBUBOWPFCH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  30
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  158
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• GENE CLUSTER FOR THE BIOSYNTHETIC PRODUCTION OF TETRACYCLINE COMPOUNDS IN A HETEROLOGOUS HOST
  申请人：Helmholtz-Zentrum für Infektionsforschung GmbH

  公开号：EP3681859B1

  公开（公告）日：2022-10-26
• Gene cluster for the biosynthetic production of tetracycline compounds in a heterologous host
  申请人：HELMHOLTZ-ZENTRUM FÜR INFEKTIONSFORSCHUNG GMBH

  公开号：US20200392071A1

  公开（公告）日：2020-12-17

  The present invention relates to the application of biosynthetic engineering for the heterologous expression of a gene cluster for the biosynthesis of tetracycline compounds, notably chelocardin and its analogues. More particularly, the present invention pertains to a gene cluster encoding polypeptides involved in tetracycline biosynthesis, which gene cluster is suitable for heterologous expression of the biosynthetic pathway in a host cell. The present invention further pertains to DNA construct s comprising the gene cluster, to recombinant heterologous host cell s comprising the gene cluster or the DNA construct, to processes for the biosynthetic production of a tetracycline compound employing such recombinant host cells, and to tetracycline compounds thereby produced. The present invention also pertains to fusion proteins which are useful in the production of tetracycline compounds.
• US8440646B1
  申请人：——

  公开号：US8440646B1

  公开（公告）日：2013-05-14