2,8-Bis-(3-chloro-1,1,2,2,3,3-hexafluoro-propyl)-pyrano[2,3-f]chromene-4,10-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2,8-Bis-(3-chloro-1,1,2,2,3,3-hexafluoro-propyl)-pyrano[2,3-f]chromene-4,10-dione
• 英文别名: 2,8-Bis(3-chloro-1,1,2,2,3,3-hexafluoropropyl)pyrano[2,3-f]chromene-4,10-dione
• 化学式: C₁₈H₄Cl₂F₁₂O₄
• 分子量: 583.114
• InChiKey: IWVFEKNOIDYGQK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  36
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  16

反应信息

• 作为产物：
  描述：

  (Z)-6-Chloro-3-(3-{4-chloro-1-[1-ethoxycarbonyl-meth-(Z)-ylidene]-2,2,3,3,4,4-hexafluoro-butoxy}-phenoxy)-4,4,5,5,6,6-hexafluoro-hex-2-enoic acid ethyl ester 在 PPA 作用下， 反应 10.0h， 以71%的产率得到2,8-Bis-(3-chloro-1,1,2,2,3,3-hexafluoro-propyl)-pyrano[2,3-f]chromene-4,10-dione
  参考文献：
  名称：

  A facile synthesis of fluoroalkylated chromones and their analogues from 2,2-dihydropolyfluoroalkanoates

  摘要：

  Fluoroalkylated chromones and their analogues have been prepared in good yield by the Michael addition reactions of 2,2-dihydropolyfluoroalkanoates with phenols in the presence of triethylamine, followed by acid-catalyzed intramolecular ring-closure.

  DOI：

  10.1016/0022-1139(93)02913-y

文献信息

• A facile synthesis of fluoroalkylated chromones and their analogues from 2,2-dihydropolyfluoroalkanoates
  作者：Wei-Yuan Huang、Yan-Song Liu、Long Lu

  DOI：10.1016/0022-1139(93)02913-y

  日期：1994.3

  Fluoroalkylated chromones and their analogues have been prepared in good yield by the Michael addition reactions of 2,2-dihydropolyfluoroalkanoates with phenols in the presence of triethylamine, followed by acid-catalyzed intramolecular ring-closure.