7-Hydroxy-6-isobutyryl-5-methoxy-2,2-dimethylbenzopyran

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 7-Hydroxy-6-isobutyryl-5-methoxy-2,2-dimethylbenzopyran
• 英文别名: 1-(7-hydroxy-5-methoxy-2,2-dimethylchromen-6-yl)-2-methylpropan-1-one
• 化学式: C₁₆H₂₀O₄
• 分子量: 276.33
• InChiKey: JGLBGRDHLZINFL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• FORMULATION FOR ENHANCED DELIVERY OF PHENETHYLAMINE
  申请人：Kneller W. Bruce

  公开号：US20070190187A1

  公开（公告）日：2007-08-16

  The present invention is directed to a formulation comprising phenethylamine or a derivative thereof, and an MAO-B enzyme inhibitor. The present invention is also directed to a method of increasing the absorption of phenethylamine or a derivative thereof, into the bloodstream, cells and tissue. The method includes administering phenethylamine or a derivative thereof, in combination with an MAO-B enzyme inhibitor.
• [EN] NEUROACTIVE PLANT EXTRACT FROM HYPERICUM POLYANTHEMUM<br/>[FR] EXTRAIT NEUROACTIF DE PLANTE OBTENU À PARTIR DE HYPERICUM POLYANTHEMUM
  申请人：UNIV ROUEN

  公开号：WO2010092162A1

  公开（公告）日：2010-08-19

  The present invention belongs to the field of plant extracts with activity on the central nervous system. Specifically, the plant extract of the present invention is an extract obtained from Hypericum polyanthemum and comprising the compound uliginosin B and/or compounds from the class of benzopyrans such as. The present invention also relates to a pharmaceutical composition comprising such an extract which has pharmacological action in psychiatric disorders, such as mood disorders, specifically, anti-depressant activity. Such as HP1 (6-isobutyryl-5,7-dimethoxy-2,2-dimethyl-benzopyran), HP2 (7-hydroxy-6-isobutyryl-5-methoxy-2,2-dimethyl-benzopyran) and HP3 (5-hydroxy-6-isobutyryl-7-methoxy-2,2-dimethyl-benzopyran)).