1-(2,4-Dihydroxyphenyl)-2-(4-hydroxyphenyl)prop-2-en-1-one | 153409-51-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 1-(2,4-Dihydroxyphenyl)-2-(4-hydroxyphenyl)prop-2-en-1-one
• CAS: 153409-51-9
• 化学式: C₁₅H₁₂O₄
• 分子量: 256.25
• InChiKey: MPNKZWIUITZJCR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• THERAPEUTIC METHODS AND COMPOSITIONS INVOLVING ISOFLAVONES
  申请人：KELLY Graham Edmund

  公开号：US20080287528A1

  公开（公告）日：2008-11-20

  Therapeutic methods of treatment, compositions and foodstuffs are described which contain isoflavone compounds described by general formula (1), in which Z is H, R 1 is H, or R A CO where R A is C 1-10 alkyl or an amino acid, R 2 is H, OH, or OR B where R B is an amino acid, or COR A where R A is as previously defined, W is H, A is H or OH, and B is selected from (a), (b), (c), or W is H, and A and B taken together form a six-membered ring selected from (d), or W, A and B taken with the groups with which they are associated comprise (e), or W and A taken together with the groups with which they are associated comprise (f) and B is (g) wherein R 3 is H, COR A where R A is as previously defined, CO 2 R C where R C is C 1-10 alkyl, or COR B where R B is as previously defined, R 4 is H, COR D where R D is H, OH, C 1-10 alkyl or an amino acid, CO 2 R C where R C is as previously defined, COR E where R E is H, C 1-10 alkyl or an amino acid, COOH, COR C where R C is as previously defined, or CONHR E where R E is as previously defined, R 5 is H, CO 2 R C where R C is as previously defined, or COR C OR E where R C and R E are as previously defined, and where the two R 5 groups are attached to the same group they are the same or different, R 6 is H or hydroxy C 1-10 alkyl, X is preferably O, but may be N or S, and Y is (h) where R 7 is H, or C 1-10 alkyl.

  本文描述了治疗方法、组合物和食品，其中包含一般式（1）所描述的异黄酮化合物，其中Z为H，R1为H或RACO，其中RA为C1-10烷基或氨基酸，R2为H、OH或ORB，其中RB为氨基酸，或CORA，其中RA如先前定义，W为H，A为H或OH，B选自（a）、（b）、（c），或W为H，A和B结合形成六元环，选自（d），或W、A和B与它们相关的基团组成（e），或W和A与它们相关的基团组成（f），B为（g），其中R3为H，CORA，其中RA如先前定义，CO2RC，其中RC为C1-10烷基，或CORB，其中RB如先前定义，R4为H，CORD，其中RD为H、OH、C1-10烷基或氨基酸，或CO2RC，其中RC如先前定义，CORE，其中RE为H、C1-10烷基或氨基酸，或COOH，CORC，其中RC如先前定义，或CONHRE，其中RE如先前定义，R5为H，CO2RC，其中RC如先前定义，或CORCORE，其中RC和RE如先前定义，且当两个R5基团连接到同一基团时，它们相同或不同，R6为H或羟基C1-10烷基，X优选为O，但也可以为N或S，Y为（h），其中R7为H或C1-10烷基。
• Therapeutic methods and compositions involving isoflavones
  申请人：Novogen Research Pty. Ltd.

  公开号：EP1927352A2

  公开（公告）日：2008-06-04

  Therapeutic methods of treatment, compositions and foodstuffs are described which contain isoflavone compounds described bathe general formula I in which Z is H, R1 is H, or RACO where RA is C1-10 alkyl or an amino acid, R2 is H, OH, or ORB where RB is an amino acid or CORA where RA is as previously defined, W is H, A is H or OH, and B is selected from or W is H, and A, and B taken together form a six membered ring selected from or W, A and B taken with the groups with which they are associated comprise or W and A taken together with the groups with which they are associated comprise and B is wherein R3 is H, CORA where RA is as previously defined , CO2RC where RC is C1-10 alkyl, or CORB where RB, is as previously defined, R4 is H, CORD where RD is H, OH, C1-10 alkyl or an amino acid, CO2RC where RC is as previously defined, CORE where RE is H, C1-10 alkyl or an amino acid, COOH, CORC where RC is as previously defined, or CONHRE where RE is as previously defined, R5 is H, CO2RC where RC is as previously defined, or CORCORE where RC and RE are as previously defined, and where the two R5 groups are attached to the same group they are the same or different, R6 is H or hydroxy C1-10 alkyl, X is preferably O, but may be N or S, and Y is where R7 is H, or C1-10 alkyl.

  描述了含有通式 I 所述异黄酮化合物的治疗方法、组合物和食品 其中 Z 是 H R1 是 H 或 RACO，其中 RA 是 C1-10 烷基或氨基酸、 R2 是 H、OH 或 ORB（其中 RB 是氨基酸）或 CORA（其中 RA 如前定义、 W 是 H，A 是 H 或 OH，B 选自 或 W 是 H，A 和 B 共同形成一个选自以下各项的六员环 或 W、A 和 B 与它们相关联的基团组成 或 W 和 A 连同与之有关联的组构成 而 B 是 其中 R3 是 H、RA 如前定义的 CORA、RC 是 C1-10 烷基的 CO2RC 或 RB 如前定义的 CORB、 R4 是 H、RD 为 H、OH、C1-10 烷基或氨基酸的 CORD、RC 如前定义的 CO2RC、RE 为 H、C1-10 烷基或氨基酸的 CORE、COOH、RC 如前定义的 CORC 或 RE 如前定义的 CONHRE、 R5 为 H，RC 如前定义的 CO2RC，或 CORCORE，其中 RC 和 RE 如前定义，当两个 R5 基团连接到同一基团上时，它们是相同的或不同的、 R6 是 H 或羟基 C1-10 烷基、 X 最好是 O，但也可以是 N 或 S，以及 Y 是 其中 R7 是 H 或 C1-10 烷基。
• Combination chemotherapy compositions and methods
  申请人：Kelly Edmund Graham

  公开号：US20080069900A1

  公开（公告）日：2008-03-20

  This invention relates to combination therapies involving anticancer chemotherapeutic agents and isoflavones or analogues thereof. The invention flier relates to compounds, compositions, methods and therapeutic uses involving, containing, comprising, including and/or for preparing platinum-isoflavonoid complexes suitable for use in the combination therapies of the invention.
• PREVENTION AND REVERSAL OF CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY
  申请人：Brown David

  公开号：US20100152284A1

  公开（公告）日：2010-06-17

  Provided herein are methods for treating or preventing neuropathy, neuropathy-related conditions, wherein the neuropathy or neuropathy-related conditions are induced by, or otherwise associated with, treatment of the subject with at least one chemotherapeutic agent, the methods comprising administering an effective amount of an isoflavonoid compound of formula (I). Also provided are methods for the treatment of nerve damage. Also provided are uses of isoflavonoid compounds of formula (I) in the treatment of neuropathy, neuropathy-related conditions and nerve damage.
• US7202273B2
  申请人：——

  公开号：US7202273B2

  公开（公告）日：2007-04-10