8,8'-bieckol dodecaacetate | 88095-82-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 单宁
• 英文名称: 8,8'-bieckol dodecaacetate
• 英文别名: 7,7'-bieckol dodeca-acetate；[3-Acetyloxy-5-[2,4,7,9-tetraacetyloxy-8-[1,3,6,8-tetraacetyloxy-9-(3,5-diacetyloxyphenoxy)dibenzo-p-dioxin-2-yl]dibenzo-p-dioxin-1-yl]oxyphenyl] acetate
• CAS: 88095-82-3
• 化学式: C₆₀H₄₆O₃₀
• 分子量: 1247.01
• InChiKey: NLKLGZXPJKRHNT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  90
• 可旋转键数：
  29
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  371
• 氢给体数：
  0
• 氢受体数：
  30

反应信息

• 作为产物：
  描述：

  8,8'-双鹅掌菜酚 、 乙酸酐 在 吡啶 作用下， 以115 mg的产率得到8,8'-bieckol dodecaacetate
  参考文献：
  名称：

  Anti-plasmin inhibitor. V. Structures of novel dimeric eckols isolated from the brown alga Ecklonia kurome Okamura.

  摘要：

  6, 6'-Bieckol (1), 2-O-(2, 4, 6-trihydroxyphenyl)-6, 6'-bieckol (4), and 8, 8'-bieckol (2), bispolyphenols with a dibenzo-1, 4-dioxin skeleton, have been isolated as potent anti-plasmin inhibitors from the brown alga Ecklonia kurome OKAMURA. Their structures have been determined to be dimers of eckol linked at the C-6 or C-8 positions, through an aryl-aryl bond on the basis of spectral data. Their inhibitory actions on anti-plasmins (α2-macroglobulin and α2-plasmin inhibitor) and some proteases have been examined.

  DOI：

  10.1248/cpb.37.2438

文献信息

• FUKUYAMA, YOSHIYASU;KODAMA, MITSUAKI;MIURA, IWAO;KINZYO, ZIUNEI;MORI, HID+, CHEM. AND PHARM. BULL., 37,(1989) N, C. 2438-2440
  作者：FUKUYAMA, YOSHIYASU、KODAMA, MITSUAKI、MIURA, IWAO、KINZYO, ZIUNEI、MORI, HID+

  DOI：——

  日期：——