6-[1-[1,3-dihydroxy-5,5,7,7-tetramethyl-4-(2-methylpropanoyl)-6,8-dioxo-9-propan-2-yl-9H-xanthen-2-yl]-2-methylpropyl]-2,2,4,4-tetramethylcyclohexane-1,3,5-trione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 6-[1-[1,3-dihydroxy-5,5,7,7-tetramethyl-4-(2-methylpropanoyl)-6,8-dioxo-9-propan-2-yl-9H-xanthen-2-yl]-2-methylpropyl]-2,2,4,4-tetramethylcyclohexane-1,3,5-trione
• 化学式: C₃₈H₅₀O₉
• 分子量: 650.8
• InChiKey: NMSNLAOCVMELEC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.9
• 重原子数：
  47
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  152
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• Cosmetic compositions containing quinones and their topical use on skin and hair
  申请人：Repairogen Corp

  公开号：US10780034B2

  公开（公告）日：2020-09-22

  Described are compositions containing quinones that show activity in enhance DNA repair and/or prevent damage to DNA. The quinones are thymoquinone, lapachol, myrtucommulone C, or mixtures thereof, and can be formulated into cosmetic compositions for topical administration to a subject in need thereof. The cosmetic compositions can also include sunscreens, surfactants, sunless tanning agents, desquamation agents, antiperspirants, colorants, preservatives and mixtures; and a cosmetically acceptable carrier. The compositions should find use in methods for treating the signs of ageing in mammals via topical application to the skin or hair of the mammals.

  所描述的是含有醌类化合物的组合物，这些醌类化合物在增强 DNA 修复和/或防止 DNA 损伤方面显示出活性。这些醌类化合物是胸腺醌、拉帕醌、桃金霉素 C 或它们的混合物，可以配制成化妆品组合物，供有需要的人局部使用。化妆品组合物还可以包括防晒剂、表面活性剂、防晒剂、去角质剂、止汗剂、着色剂、防腐剂和混合物；以及化妆品上可接受的载体。这些组合物可用于哺乳动物皮肤或毛发的局部使用，以治疗哺乳动物的衰老迹象。
• COSMETIC COMPOSITIONS CONTAINING QUINONES AND THEIR TOPICAL USE ON SKIN AND HAIR
  申请人：Repairogen Corp

  公开号：US20180116928A1

  公开（公告）日：2018-05-03

  Described are compositions containing quinones that show activity in enhance DNA repair and/or prevent damage to DNA. The quinones are thymoquinone, lapachol, myrtucommulone C, or mixtures thereof, and can be formulated into cosmetic compositions for topical administration to a subject in need thereof. The cosmetic compositions can also include sunscreens, surfactants, sunless tanning agents, desquamation agents, antiperspirants, colorants, preservatives and mixtures; and a cosmetically acceptable carrier. The compositions should find use in methods for treating the signs of ageing in mammals via topical application to the skin or hair of the mammals.