annulin B

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并吡喃类
• 英文名称: annulin B
• 英文别名: methyl 8-ethyl-9-hydroxy-2,4,4,7-tetramethyl-3,5,10-trioxo-4a,10a-dihydrobenzo[g]chromene-2-carboxylate
• 化学式: C₂₁H₂₄O₇
• 分子量: 388.4
• InChiKey: OHWPXNCKGWEEQM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  107
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Method for treating cancer using chemokine antagonists
  申请人：Syntrix Biosystems Inc.

  公开号：US10660909B2

  公开（公告）日：2020-05-26

  What is described is a method for treating cancer in a patient in need of such treatment through the use of an antagonist to CXCR1 and/or CXCR2 receptors by administering a therapeutically effective amount of an antagonist of CXCR1 and/or CXCR2, or pharmaceutical compositions thereof, either alone as monotherapy, or in combination with at least one other anticancer therapy.

  所描述的是一种通过使用 CXCR1 和/或 CXCR2 受体拮抗剂治疗需要此类治疗的患者癌症的方法，其方法是施用治疗有效量的 CXCR1 和/或 CXCR2 拮抗剂或其药物组合物，既可单独作为单一疗法，也可与至少一种其他抗癌疗法联合使用。
• INDOLEAMINE 2,3-DIOXYGENASE PATHWAYS IN THE GENERATION OF REGULATORY T CELLS
  申请人：Chen Wei

  公开号：US20090155311A1

  公开（公告）日：2009-06-18

  The present invention provides methods for the control of the generation of regulatory T cells (Tregs) and uses thereof.
• METHOD FOR TREATING CANCER USING CHEMOKINE ANTAGONISTS
  申请人：Syntrix Biosystems Inc.

  公开号：US20180177808A1

  公开（公告）日：2018-06-28

  What is described is a method for treating cancer in a patient in need of such treatment through the use of an antagonist to CXCR1 and/or CXCR2 receptors by administering a therapeutically effective amount of an antagonist of CXCR1 and/or CXCR2, or pharmaceutical compositions thereof, either alone as monotherapy, or in combination with at least one other anticancer therapy.
• [EN] INDOLEAMINE 2,3-DIOXYGENASE PATHWAYS IN THE GENERATION OF REGULATORY T CELLS<br/>[FR] VOIES D'INDOLÉAMINE 2,3-DIOXYGÉNASE DANS LA PRODUCTION DE LYMPHOCYTES T RÉGULATEURS
  申请人：MED COLLEGE GEORGIA RES INST

  公开号：WO2007081878A2

  公开（公告）日：2007-07-19

  (EN) The present invention provides methods for the control of the generation of regulatory T cells (Tregs) and uses thereof.(FR) L'invention concerne des méthodes de lutte contre la production de lymphocytes T régulateurs (Tregs) et des utilisations de celles-ci.
• [EN] METHOD FOR TREATING CANCER USING CHEMOKINE ANTAGONISTS ALONE OR IN COMBINATION<br/>[FR] MÉTHODE DE TRAITEMENT DU CANCER À L'AIDE D'ANTAGONISTES DE CHIMIOKINE SEULS OU EN COMBINAISON
  申请人：SYNTRIX BIOSYSTEMS INC

  公开号：WO2019165315A1

  公开（公告）日：2019-08-29

  What is described is a method for treating cancer in a patient in need of such treatment through the use of an antagonist to CXCR1 and/or CXCR2 receptors by administering a therapeutically effective amount of an antagonist of CXCR1 and/or CXCR2, or pharmaceutical compositions thereof, either alone as monotherapy, or in combination with at least one other anticancer therapy.