N-[(E)-[4-[4-[4-[(E)-(phenylhydrazono)methyl]phenyl]piperazin-1-yl]phenyl]methyleneamino]aniline | 102827-57-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: N-[(E)-[4-[4-[4-[(E)-(phenylhydrazono)methyl]phenyl]piperazin-1-yl]phenyl]methyleneamino]aniline
• 英文别名: N-[(E)-[4-[4-[4-[(E)-(phenylhydrazinylidene)methyl]phenyl]piperazin-1-yl]phenyl]methylideneamino]aniline
• CAS: 102827-57-6
• 化学式: C₃₀H₃₀N₆
• 分子量: 474.608
• InChiKey: STHOLVQORPIXKI-QBRCKEFASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  36
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  55.3
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  对氟苯甲醛 以 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 生成 N-[(E)-[4-[4-[4-[(E)-(phenylhydrazono)methyl]phenyl]piperazin-1-yl]phenyl]methyleneamino]aniline
  参考文献：
  名称：

  Piperazine-linked bisbenzamidines: a novel class of antileishmanial agents

  摘要：

  A series of 13 1,4-diarylpiperazines has been prepared, evaluated for antileishmanial activity and their binding affinity to DNA was measured. Among these compounds, 1,4-bis[4-(1H-benzimidazol-2-yl)phenyl]piperazine (14) emerged as the most active compound with an IC50 value of 0.41 muM which is about sevenfold more potent than pentamidine. (C) 2004 Elsevier SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2004.01.009

文献信息

• Piperazine-linked bisbenzamidines: a novel class of antileishmanial agents
  作者：Annie Mayence、Jean Jacques Vanden Eynde、Louis LeCour、Larry A. Walker、Babu L. Tekwani、Tien L. Huang

  DOI：10.1016/j.ejmech.2004.01.009

  日期：2004.6

  A series of 13 1,4-diarylpiperazines has been prepared, evaluated for antileishmanial activity and their binding affinity to DNA was measured. Among these compounds, 1,4-bis[4-(1H-benzimidazol-2-yl)phenyl]piperazine (14) emerged as the most active compound with an IC50 value of 0.41 muM which is about sevenfold more potent than pentamidine. (C) 2004 Elsevier SAS. All rights reserved.