1-Hydroxy-6,6,9-trimethyl-3-(2-phenylethyl)-6a,7,8,10a-tetrahydrobenzo[c]chromene-2-carboxylic acid

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 1-Hydroxy-6,6,9-trimethyl-3-(2-phenylethyl)-6a,7,8,10a-tetrahydrobenzo[c]chromene-2-carboxylic acid
• 英文别名: 1-hydroxy-6,6,9-trimethyl-3-(2-phenylethyl)-6a,7,8,10a-tetrahydrobenzo[c]chromene-2-carboxylic acid
• 化学式: C₂₅H₂₈O₄
• 分子量: 392.5
• InChiKey: OWFXHGABDKORFT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] OPTIMIZED OLIVETOLIC ACID CYCLASE POLYPEPTIDES<br/>[FR] POLYPEPTIDES CYCLASE D'ACIDE OLIVETOLIQUE OPTIMISÉS
  申请人：DEMETRIX INC

  公开号：WO2021183448A1

  公开（公告）日：2021-09-16

  The present disclosure provides engineered variants of an olivetolic acid cyclase polypeptide, wherein the engineered variants comprise an amino acid sequence of SEQ ID NO:1 comprising at least one amino acid substitution, nucleic acids comprising nucleotide sequences encoding said engineered variants, methods of making modified host cells comprising said nucleic acids, modified host cells expressing said engineered variants, methods of producing olivetolic acid, olivetolic acid derivatives, cannabinoids or cannabinoid derivatives, and methods of screening engineered variants of the olivetolic acid cyclase polypeptide.