comaparvin | 34434-17-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并吡喃类
• 英文名称: comaparvin
• 英文别名: 5,8-dihydroxy-10-methoxy-2-propylbenzo[h]chromen-4-one
• CAS: 34434-17-8
• 化学式: C₁₇H₁₆O₅
• 分子量: 300.311
• InChiKey: POMCQPYWKLKBSX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  comaparvin 生成 comaparvin 8-O-methyl ether
  参考文献：
  名称：

  SAKUMA, YOSHIAKI;TANAKA, JUNICHI;HIGA, TATSUO, AUSTRAL. J. CHEM., 40,(1987) N 9, 1613-1616

  摘要：

  DOI：

文献信息

• Sakuma, Yoshiaki; Tanaka, Jun'ichi; Higa, Tatsuo, Australian Journal of Chemistry, <hi>1987</hi>, vol. 40, # 9, p. 1613 - 1616
  作者：Sakuma, Yoshiaki、Tanaka, Jun'ichi、Higa, Tatsuo

  DOI：——

  日期：——
• METHOD OF INHIBITING ABCG2 AND OTHER TREATMENT METHODS
  申请人：The United States of America, as represented by the Secretary, Department of Health and Human

  公开号：US20130274323A1

  公开（公告）日：2013-10-17

  Disclosed are methods of enhancing the chemotherapeutic treatment of tumor cells, reducing resistance of a cancer cell to a chemotherapeutic agent, a method of inhibiting ABCG2, Pgp, or MRP1 in a mammal afflicted with cancer, and a method of increasing the bioavailability of an ABCG2 substrate drug in a mammal. The methods comprise administering effective amounts of certain compounds to the mammal, for example, a compound of the formula (I): wherein R 1 , R 2 , R 3 , X 1 , X 2 , X 3 , a, and b are as described herein. Uses of these compounds in the preparation of a medicament are also disclosed. Also disclosed are compounds of formula (II), pharmaceutical compositions comprising such compounds and uses thereof.
• US8470888B2
  申请人：——

  公开号：US8470888B2

  公开（公告）日：2013-06-25
• US9314448B2
  申请人：——

  公开号：US9314448B2

  公开（公告）日：2016-04-19