6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione | 38554-25-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 并四苯
• 英文名称: 6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione
• CAS: 38554-25-5
• 化学式: C₂₁H₁₈O₈
• 分子量: 398.4
• InChiKey: QHGFPRZWWKUHKF-UHFFFAOYSA-N

物化性质

• 熔点：
  >205°C (dec.)
• 沸点：
  742.7±60.0 °C(Predicted)
• 密度：
  1.587±0.06 g/cm3(Predicted)
• 溶解度：
  DMSO（轻微）、甲醇（轻微、加热、超声处理）

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  141
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

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  申请人：Synbias Pharma AG

  公开号：EP2778172B1

  公开（公告）日：2017-02-01
• Methods and compositions for the treatment of cancer
  申请人：Kink A. John

  公开号：US20080095755A1

  公开（公告）日：2008-04-24

  The present invention is directed toward the delivery of toxic agents to pathogenic cells, particularly cancer cells. In some embodiments, the toxic agent is a human ribonuclease or similar agent that is toxic to cells.
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  申请人：Klink Tony

  公开号：US20100080789A1

  公开（公告）日：2010-04-01

  The present invention relates to the use of ribonucleases (RNases) in the treatment or prevention of disease.
• METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER
  申请人：Kink John A

  公开号：US20130078229A1

  公开（公告）日：2013-03-28

  The present invention is directed toward the delivery of toxic agents to pathogenic cells, particularly cancer cells. In some embodiments, the toxic agent is a human ribonuclease or similar agent that is toxic to cells.
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  申请人：——

  公开号：US8029782B2

  公开（公告）日：2011-10-04