2-(N-Methylperfluorooctanesulfonamido)acetic acid | 2355-31-9

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代烷
• 英文名称: 2-(N-Methylperfluorooctanesulfonamido)acetic acid
• 英文别名: 2-[1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctylsulfonyl(methyl)amino]acetic acid
• CAS: 2355-31-9
• 化学式: C₁₁H₆F₁₇NO₄S
• 分子量: 571.21
• InChiKey: QNDHIRFIMVNHBN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  34
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  83.1
• 氢给体数：
  1
• 氢受体数：
  22

文献信息

• [EN] PFKFB3 INHIBITORS AND THEIR USES<br/>[FR] INHIBITEURS DE PFKFB3 ET LEURS UTILISATIONS
  申请人：GERO DISCOVERY LLC

  公开号：WO2020080979A1

  公开（公告）日：2020-04-23

  This disclosure relates to new phthalimide and isoindolinone derivatives and other PFKFB3 inhibitors for use in the treatment of diseases. The invention further relates to pharmaceutical compositions containing such PFKFB3 inhibitors, methods of preparation thereof, methods for their use as therapeutic agents, and methods of preparation of a medicament for use in therapy, as well as kits and other inventiions comprising such PFKFB3 inhibitors. These PFKFB3 inhibitors are useful for the treatment and prophylaxis of cancer, neurodegenerative diseases, autoimmune diseases, inflammatory disorders, multiple sclerosis, metabolic diseases, inhibition of angiogenesis and other diseases and conditions, where the modulation of PFKFB3 and/or PFKFB4 has beneficial effect as well as neuroprotection.

  这项披露涉及新的邻苯二甲酰亚胺和异吲哚酮衍生物以及其他PFKFB3抑制剂，用于治疗疾病。该发明还涉及含有此类PFKFB3抑制剂的药物组合物，其制备方法，作为治疗剂的使用方法，以及用于治疗的药物的制备方法，以及包含此类PFKFB3抑制剂的工具包和其他发明。这些PFKFB3抑制剂对于治疗和预防癌症、神经退行性疾病、自身免疫疾病、炎症性疾病、多发性硬化症、代谢性疾病、抑制血管生成以及其他疾病和情况具有用途，在这些情况下，PFKFB3和/或PFKFB4的调节具有益处，以及神经保护作用。
• Methods and systems for biomonitoring
  申请人：Newomics Inc.

  公开号：US10627395B2

  公开（公告）日：2020-04-21

  The present disclosure provides methods and systems for detecting a presence or absence of one or more analytes in small volumes of samples. The detected presence or absence of the one or more analytes can be used for a variety of applications including biomonitoring.

  本公开提供了检测少量样品中是否存在一种或多种分析物的方法和系统。检测到的一种或多种分析物的存在与否可用于多种应用，包括生物监测。
• Composition and method for capture and degradation of PFAS
  申请人：Battelle Memorial Institute

  公开号：US11518689B2

  公开（公告）日：2022-12-06

  Materials for binding per- and polyfluoroalkyl substances (PFAS) are disclosed. A fluidic device comprising the materials for detection and quantification of PFAS in a sample is disclosed. The fluidic device may be configured for multiplexed analyses. Also disclosed are methods for sorbing and remediating PFAS in a sample. The sample may be groundwater containing, or suspected of containing, one or more PFAS.

  本发明公开了用于结合全氟和多氟烷基物质（PFAS）的材料。还公开了一种流体装置，其中包含用于检测和定量样品中 PFAS 的材料。该流体装置可用于多重分析。还公开了吸附和修复样品中 PFAS 的方法。样品可以是含有或怀疑含有一种或多种 PFAS 的地下水。
• METHODS AND SYSTEMS FOR BIOMONITORING
  申请人：Newomics Inc.

  公开号：US20180038850A1

  公开（公告）日：2018-02-08

  The present disclosure provides methods and systems for detecting a presence or absence of one or more analytes in small volumes of samples. The detected presence or absence of the one or more analytes can be used for a variety of applications including biomonitoring.
• COMPOSITION AND METHOD FOR CAPTURE AND DEGRADATION OF PFAS
  申请人：Battelle Memorial Institute

  公开号：US20200369536A1

  公开（公告）日：2020-11-26

  Materials for binding per- and polyfluoroalkyl substances (PFAS) are disclosed. A fluidic device comprising the materials for detection and quantification of PFAS in a sample is disclosed. The fluidic device may be configured for multiplexed analyses. Also disclosed are methods for sorbing and remediating PFAS in a sample. The sample may be groundwater containing, or suspected of containing, one or more PFAS.