Platynecin | 113427-38-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯里西啶类
• 英文名称: Platynecin
• 英文别名: Mikanecin；7-(hydroxymethyl)-2,3,5,6,7,8-hexahydro-1H-pyrrolizin-1-ol
• CAS: 113427-38-6
• 化学式: C₈H₁₅NO₂
• mdl: MFCD30479576
• 分子量: 157.213
• InChiKey: QWOXSTGOGUNUGF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  43.7
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Method And Assay Kit For Detection Of Toxicity Induced By Pyrrolizidine Alkaloids
  申请人：Lin Ge

  公开号：US20130189710A1

  公开（公告）日：2013-07-25

  An antibody, which specifically recognizes adducts between pyrrole and cellular macromolecules. Such adducts are likely to occur in mammals suffering an incident of pyrrolizidine alkaloid poisoning. The antibody can be produced using a synthetic immunogen conjugated with a pyrrole as a hapten and it can be used, for example in an assay kit and/or by itself, as a novel means for detecting or diagnosing pyrrolizidine alkaloid poisoning both clinics and research laboratories.

  一种抗体，特异性识别吡咯与细胞大分子之间的加合物。这种加合物很可能在哺乳动物遭受吡咯啉生物碱中毒事件时发生。该抗体可以使用与吡咯偶联的合成免疫原作为半抗原来生产，并且可以用作检测或诊断吡咯啉生物碱中毒的新方法，例如在检测试剂盒和/或单独使用，无论是在临床还是研究实验室中。
• US9056916B2
  申请人：——

  公开号：US9056916B2

  公开（公告）日：2015-06-16
• [EN] BIOMARKERS AND METHODS FOR NON-INVASIVE DETECTION OF HEPATOTOXIC PYRROLIZIDINE ALKALOID EXPOSURE<br/>[FR] BIOMARQUEURS ET PROCÉDÉS POUR LA DÉTECTION NON INVASIVE D'EXPOSITION À DES ALCALOÏDES DE PYRROLIZIDINE HÉPATOTOXIQUE
  申请人：UNIV HONG KONG CHINESE

  公开号：WO2021180086A1

  公开（公告）日：2021-09-16

  The present disclosure discloses non-invasive methods and kits for detecting, diagnosing, or monitoring pyrrolizidine alkaloid exposure in a subject, by measuring the amount or concentration of pyrrole-amino acid adduct in a biological sample (e.g., urine) from the subject and comparing the amount or concentration of pyrrole-amino acid adduct with a reference control subject.