1-(1,7-dihydroxy-8,8,10a-trimethyl-6,7,8a,9-tetrahydro-5H-xanthen-4-yl)-3-(4-hydroxyphenyl)prop-2-en-1-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 1-(1,7-dihydroxy-8,8,10a-trimethyl-6,7,8a,9-tetrahydro-5H-xanthen-4-yl)-3-(4-hydroxyphenyl)prop-2-en-1-one
• 化学式: C₂₅H₂₈O₅
• 分子量: 408.5
• InChiKey: QWEMHRHZLRHHEN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  30
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  87
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Therapeutic agent
  申请人：Enoki Tatsuji

  公开号：US20070092551A1

  公开（公告）日：2007-04-26

  A therapeutic agent and prophylactic agent for a disease accompanying an abnormality in an amount of insulin or insulin response, an agent for an insulin-mimetic action, a food, beverage and feed, an agent for enhancing glucose uptake into a cell, and an agent for inducing differentiation into an adipocyte, characterized in that each comprises as an effective ingredient at least one compound selected from the group consisting of a chalcone compound, an acetophenone compound, a coumarin compound, a phthalide compound, derivatives thereof, and pharmacologically acceptable salts thereof.

  一种治疗伴随胰岛素或胰岛素反应异常的疾病的治疗剂和预防剂，一种具有类胰岛素作用的剂，一种食品、饮料和饲料，一种增强葡萄糖进入细胞的剂，以及一种诱导分化成脂肪细胞的剂，其特征在于每种剂都包含至少一种有效成分，所述有效成分选自香豆素类化合物、苯乙酮类化合物、香豆酮类化合物、邻苯二甲酸酯类化合物及其衍生物和药学上可接受的盐。
• REMEDIES
  申请人：TAKARA BIO INC.

  公开号：EP1563841A1

  公开（公告）日：2005-08-17

  The present invention relates to a therapeutic agent or prophylactic agent for a disease requiring promotion of osteogenesis or enhancement of bone morphogenetic protein production, an agent for promotion of osteogenesis or an agent for enhancement of bone morphogenetic protein production, and a food, beverage or feed for promotion of osteogenesis or enhancement of bone morphogenetic protein production, characterized in that each comprises as an effective ingredient a processed product derived from a plant. Also, the present invention relates to a method for measuring an enhancing action for bone morphogenetic protein production, a method for screening a substance having an enhancing action for bone morphogenetic protein production, and a method for preparing a substance having an enhancing action for bone morphogenetic protein production, each method using a specified cell.

  本发明涉及一种需要促进骨生成或增强骨形态发生蛋白生成的疾病的治疗剂或预防剂，一种促进骨生成或增强骨形态发生蛋白生成的制剂，以及一种促进骨生成或增强骨形态发生蛋白生成的食品、饮料或饲料，其特征在于，每种制剂都包含一种从植物中提取的加工产品作为有效成分。此外，本发明还涉及一种测量骨形态发生蛋白生成增强作用的方法、一种筛选具有骨形态发生蛋白生成增强作用的物质的方法，以及一种制备具有骨形态发生蛋白生成增强作用的物质的方法，每种方法都使用特定的细胞。
• Remedies
  申请人：Ohnogi Hiromu

  公开号：US20050272809A1

  公开（公告）日：2005-12-08

  The present invention relates to a novel chalcone compound represented by the following general formula: wherein R 1 and R 2 are taken together with the carbon atom to which they are bound, respectively, to form a hydroxydimethyl hexane ring, or where R 1 is a hydroxyl group, R 2 is an isohexenyl group, a derivative thereof, or a salt thereof. Also, the present invention relates to a therapeutic agent or prophylactic agent for a disease requiring neuronal protection, suppression for nitrogen monoxide (NO) production, inhibition for aldose reductase or suppression for interleukin production, and a food, beverage or feed for treatment or prevention of the above-mentioned disease, characterized in that each comprises the above-mentioned compound as an effective ingredient.

  本发明涉及一种由以下通式表示的新型查尔酮化合物： 其中 R 1 和 R 2 分别与它们所结合的碳原子一起形成羟基二甲基己烷环，或其中 R 1 是羟基，R 2 是异己烯基、其衍生物或其盐。此外，本发明还涉及一种用于需要保护神经元、抑制一氧化氮（NO）产生、抑制醛糖还原酶或抑制白细胞介素产生的疾病的治疗剂或预防剂，以及一种用于治疗或预防上述疾病的食品、饮料或饲料，其特征在于每一种都包含上述化合物作为有效成分。
• EP1623704A1
  申请人：——

  公开号：EP1623704A1

  公开（公告）日：2006-02-08
• Food beverage or feed for the promotion of osteogenesis comprising umbelliferae, liliaceae or compositae plant species
  申请人：Ohnogi Hiromu

  公开号：US20080008773A1

  公开（公告）日：2008-01-10

  The present invention relates to a therapeutic agent or prophylactic agent for a disease requiring promotion of osteogenesis or enhancement of bone morphogenetic protein production, an agent for promotion of osteogenesis or an agent for enhancement of bone morphogenetic protein production, and a food, beverage or feed for promotion of osteogenesis or enhancement of bone morphogenetic protein production, characterized in that each comprises as an effective ingredient a processed product derived from a plant. Also, the present invention relates to a method for measuring an enhancing action for bone morphogenetic protein production, a method for screening a substance having an enhancing action for bone morphogenetic protein production, and a method for preparing a substance having an enhancing action for bone morphogenetic protein production, each method using a specified cell.