Methyl 2-(3-ethyl-7a-hydroxy-8-methoxy-2,3,4,6,7,12b-hexahydro-1H-indolo[2,3-a]quinolizin-2-yl)-3-methoxyprop-2-enoate

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 柯楠因类生物碱
• 英文名称: Methyl 2-(3-ethyl-7a-hydroxy-8-methoxy-2,3,4,6,7,12b-hexahydro-1H-indolo[2,3-a]quinolizin-2-yl)-3-methoxyprop-2-enoate
• 英文别名: methyl 2-(3-ethyl-7a-hydroxy-8-methoxy-2,3,4,6,7,12b-hexahydro-1H-indolo[2,3-a]quinolizin-2-yl)-3-methoxyprop-2-enoate
• 化学式: C₂₃H₃₀N₂O₅
• 分子量: 414.5
• InChiKey: RYENLSMHLCNXJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  80.6
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Compound and method for treating spasms, inflammation and pain
  申请人：Kariman Alexander

  公开号：US10751380B2

  公开（公告）日：2020-08-25

  The disclosed invention generally relates to pharmaceutical and nutraceutical compounds and methods for reducing inflammation, muscle spasms, and pain associated with cancer, trauma, medical procedure, neurological diseases and disorders, as well as other conditions in subjects in need thereof. The disclosed invention further relates to Mitragyna speciose and Cannabis sativa based compounds and synthetic analogs of the alkaloids found in said plants, where said compounds can also contain a pharmacologically inactive substance for modifying certain qualities of said compounds.

  本发明一般涉及药物和营养保健品化合物及方法，用于减轻炎症、肌肉痉挛以及与癌症、创伤、医疗过程、神经系统疾病和失调有关的疼痛，以及有需要的受试者的其他病症。本发明还涉及到基于密蒙花（Mitragyna speciose）和大麻（Cannabis sativa）的化合物以及在上述植物中发现的生物碱的合成类似物，其中所述化合物还可以含有一种药理上无活性的物质，用于改变所述化合物的某些性质。
• COMPOUND AND METHOD FOR REDUCING APPETITE, FATIGUE AND PAIN
  申请人：Kariman Alexander

  公开号：US20180169172A1

  公开（公告）日：2018-06-21

  The disclosed invention generally relates to pharmaceutical and nutraceutical compounds and methods for reducing appetite, muscle fatigue and spasticity, enhancing athletic performance, and treating pain associated with cancer, trauma, medical procedure, and neurological diseases and disorders in subjects in need thereof. The disclosed invention further relates to Kratom compounds where said compound contains at least some pharmacologically inactive component.
• COMPOUND AND METHOD FOR TREATING SPASMS, INFLAMMATION AND PAIN
  申请人：Kariman Alexander

  公开号：US20180193399A1

  公开（公告）日：2018-07-12

  The disclosed invention generally relates to pharmaceutical and nutraceutical compounds and methods for reducing inflammation, muscle spasms, and pain associated with cancer, trauma, medical procedure, neurological diseases and disorders, as well as other conditions in subjects in need thereof. The disclosed invention further relates to Mitragyna speciose and Cannabis sativa -based compounds and synthetic analogs of the alkaloids found in said plants, where said compounds can also contain a pharmacologically inactive substance for modifying certain qualities of said compounds.
• COMPOUND AND METHOD FOR REDUCING NEUROPATHIC PAIN AND DEPRESSION
  申请人：Kariman Alexander

  公开号：US20190255036A1

  公开（公告）日：2019-08-22

  The disclosed invention generally relates to pharmaceutical and nutraceutical compounds and methods for reducing neuropathic pain and depression caused by toxicity, metabolism abnormality, trauma, compression, autoimmune abnormality, congenital/hereditary abnormality, infection, abnormally activated neuronal circuits, emotional stress, chemical imbalance, mental health disorder, or other causes in subjects in need thereof. The disclosed invention further relates to naturally occurring, synthetic and semi-synthetic multifunctional compounds that exhibit antidepressant and analgesic activity where said compound contains a pharmacologically inactive substance.