6,7-dimethoxy-3-(4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-1,3-dihydro-2-benzofuran-1-ol | 80666-03-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 6,7-dimethoxy-3-(4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-1,3-dihydro-2-benzofuran-1-ol
• CAS: 80666-03-1
• 化学式: C₂₂H₂₅NO₇
• 分子量: 415.4
• InChiKey: TZNFGVJRQISOHK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  78.8
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• Compositions and methods for making noscapine and synthesis intermediates thereof
  申请人：Willow BioSciences Inc.

  公开号：US10793885B2

  公开（公告）日：2020-10-06

  Methods for the manufacture of the therapeutic chemical compound noscapine and noscapine synthesis intermediates comprising contacting a noscapine pathway precursor selected from a first canadine derivative, a first papaveroxine derivative and narcotine hemiacetal with at least one of the enzymes selected from the group CYP82Y1, CYP82X1, AT1, CYP82X2, OMT, CXE1 and NOS.

  生产治疗用化学合成物诺卡平和诺卡平合成中间体的方法，包括将选自第一卡那定衍生物、第一罂粟碱衍生物和麻醉品半缩醛的诺卡平途径前体与选自CYP82Y1、CYP82X1、AT1、CYP82X2、OMT、CXE1和NOS组的至少一种酶接触。
• Methods of preventing or treating flavivirus virus infections and methods of inhibiting the entry of flvivirus, enterovirus or lentivirus into host cells
  申请人：City University of Hong Kong

  公开号：US11357771B2

  公开（公告）日：2022-06-14

  A method of preventing or treating a subject suffering from a flavivirus infection by administering an effective amount of berbamine or its analogue to the subject, berbamine has a structure of Formula (I), wherein the flavivirus infection is caused by Japanese encephalitis virus, Zika virus or Dengue virus. A method of inhibiting the entry of a flavivirus, an enterovirus and/or a lentivirus into host cells includes contacting the host cells with an effective amount of berbamine of its analogue, berbamine has a structure of Formula (I), wherein the flavivirus is Japanese encephalitis virus, Zika virus or Dengue virus.

  一种通过向受试者施用有效量的小檗胺或其类似物来预防或治疗黄病毒感染的方法，小檗胺具有式(I)的结构，其中黄病毒感染是由日本脑炎病毒、寨卡病毒或登革病毒引起的。一种抑制黄病毒、肠道病毒和/或慢病毒进入宿主细胞的方法，包括使宿主细胞与有效量的伯胺或其类似物接触，伯胺具有式（I）的结构，其中黄病毒是日本脑炎病毒、寨卡病毒或登革病毒。
• COMPOSITIONS AND METHODS FOR MAKING NOSCAPINE AND SYNTHESIS INTERMEDIATES THEREOF
  申请人：EPIMERON INC.

  公开号：US20160201101A1

  公开（公告）日：2016-07-14

  Methods for the manufacture of the therapeutic chemical compound noscapine and noscapine synthesis intermediates comprising contacting a noscapine pathway precursor selected from a first canadine derivative, a first papaveroxine derivative and narcotine hemiacetal with at least one of the enzymes selected from the group CYP82Y1, CYP82X1, AT1, CYP82X2, OMT, CXE1 and NOS.
• METHODS OF PREVENTING OR TREATING FLAVIVIRUS VIRUS INFECTIONS AND METHODS OF INHIBITING THE ENTRY OF FLVIVIRUS, ENTEROVIRUS OR LENTIVIRUS INTO HOST CELLS
  申请人：City University of Hong Kong

  公开号：US20210060002A1

  公开（公告）日：2021-03-04

  A method of preventing or treating a subject suffering from a flavivirus infection by administering an effective amount of berbamine or its analogue to the subject, berbamine has a structure of Formula (I), wherein the flavivirus infection is caused by Japanese encephalitis virus, Zika virus or Dengue virus. A method of inhibiting the entry of a flavivirus, an enterovirus and/or a lentivirus into host cells includes contacting the host cells with an effective amount of berbamine of its analogue, berbamine has a structure of Formula (I), wherein the flavivirus is Japanese encephalitis virus, Zika virus or Dengue virus.
• [EN] USE OF BERBAMINE OR ITS ANALOGUE FOR PREVENTING OR TREATING RNA VIRUS INFECTION<br/>[FR] UTILISATION DE BERBAMINE OU DE SON ANALOGUE POUR LA PRÉVENTION OU LE TRAITEMENT D'UNE INFECTION PAR LE VIRUS DE L'ARN
  申请人：UNIV CITY HONG KONG

  公开号：WO2021043234A1

  公开（公告）日：2021-03-11

  Provided herein is a method of preventing or treating a subject suffering from a flavivirus infection by administering an effective amount of berbamine or its analogue to the subject, berbamine has a structure of Formula (I), wherein the flavivirus infection is caused by Japanese encephalitis virus, Zika virus or Dengue virus, and a method of inhibiting the entry of a flavivirus, an enterovirus and/or a lentivirus into host cells, comprising contacting the host cells with an effective amount of berbamine of its analogue, berbamine has a structure of Formula (I), wherein the flavivirus is Japanese encephalitis virus, Zika virus or Dengue virus. Also provided is a method of preventing or treating a subject suffering from a coronavirus, particularly the coronavirus is SARS-CoV-2 or MERS-CoV, a method of inhibiting the entry of a coronavirus into host cells, as well as use of berbamine or its analogue in the preparation of a medicament for preventing or treating a flavivirus infection, enterovirus infection, lentivirus infection or coronavirus infection.