5-Chromeno[2,3-c]pyridin-5-ylidenechromeno[2,3-c]pyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 5-Chromeno[2,3-c]pyridin-5-ylidenechromeno[2,3-c]pyridine
• 英文别名: 5-chromeno[2,3-c]pyridin-5-ylidenechromeno[2,3-c]pyridine
• 化学式: C₂₄H₁₄N₂O₂
• 分子量: 362.387
• InChiKey: UDNTYFHPLXXPLF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  28
• 可旋转键数：
  0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  44.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-Chromeno[2,3-c]pyridin-5-ylidenechromeno[2,3-c]pyridine 、 硫酸二甲酯 以 氯仿 为溶剂， 以64%的产率得到2-Methyl-5-(2-methylchromeno[2,3-c]pyridin-2-ium-5-ylidene)chromeno[2,3-c]pyridin-2-ium
  参考文献：
  名称：

  用于活细胞成像的溶酶体特异性光活化探针的合成和性质

  摘要：

  我们描述了活细胞成像的一类新的大型斯托克斯位移溶酶体特异性光激活探针的合成和应用。

  DOI：

  10.1039/c5sc01601k

文献信息

• Synthesis and Conformational Dynamics of the Reported Structure of Xylopyridine A
  作者：Robert-André F. Rarig、Mai N. Tran、David M. Chenoweth

  DOI：10.1021/ja404737q

  日期：2013.6.19

  Natural products have served as a rich source for the discovery of new nucleic acid targeting molecules for more than half a century. However, our ability to design molecules that bind nucleic acid motifs in a sequence- and/or structure-selective manner is still in its infancy. Xylopyridine A, a naturally occurring molecule of unprecedented architecture, has been found to bind DNA by a unique mode of intercalation. Here we show that the structure proposed for xylopyridine A is not consistent with the characterization in the original isolation report and does not bind B-form DNA. Instead, we report that the originally proposed structure for xylopyridine A represents a new class of conformationally dynamic structure-selective quadruplex nucleic acid binder. The unique molecular conformation locks out nonspecific intercalative binding modes and provides a starting point for the design of a new class of structure-specific nucleic acid binder.