5-[2-(3,5-Dimethoxyphenyl)ethenyl]-2-methoxyphenol

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 5-[2-(3,5-Dimethoxyphenyl)ethenyl]-2-methoxyphenol
• 化学式: C₁₇H₁₈O₄
• 分子量: 286.32
• InChiKey: UQIWTPQGJCCTPA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  47.9
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• CAJANINE STRUCTURE ANALOGOUS COMPOUND, PREPARATION METHOD AND USE
  申请人：INSTITUTE OF MEDICINAL BIOTECHNOLOGY. CHINESE ACADEMY OF MEDICAL SCIENCES

  公开号：US20140371232A1

  公开（公告）日：2014-12-18

  Provided are cajanine structure analogous compounds, synthesis method and pharmacological effects thereof, the compounds of the present invention having the structure as represented by general formulas I, II, III, IV and V. Also provided are pharmaceutical compositions containing the compounds as active ingredient, and uses thereof; the compounds of the present invention having the pharmacological activities such as anti-virus, anti-virus-infection, nerve protection, anti-metabolic-diseases and the like. Also provided is a chemical total synthesis preparation method of the natural products cajanine, cajanine A and cajanine C. The present invention lays a foundation for the in-depth study and development of the compounds as clinical drugs in the future.

  提供的是与咖啡碱结构类似的化合物、合成方法及其药理效果，本发明的化合物具有如公式I、II、III、IV和V所代表的结构。还提供了含有这些化合物的药物组合物，以及它们的使用方法；本发明的化合物具有诸如抗病毒、抗病毒感染、神经保护、抗代谢性疾病等药理活性。还提供了天然产物咖啡碱、咖啡碱A和咖啡碱C的化学全合成制备方法。本发明为这些化合物作为未来临床药物深入研究和发展奠定了基础。
• STILBENE DERIVATIVES AS NEW CANCER THERAPEUTIC AGENTS
  申请人：Lee Ruey-min

  公开号：US20080261982A1

  公开（公告）日：2008-10-23

  Stilbene derivatives exhibit killing and suppression of growth activity against a variety of cancer cells, and are effective at suppressing tumor growth in vivo. The stilbene derivatives may be used in the treatment of diseases characterized by cell hyperproliferation including human malignancies and non-malignant diseases such as liver cirrhosis. Stilbenes may also disrupt abnormal vessels in tumor to achieve vascular disrupting effect to suppress tumor growth. Water soluble pro-drug forms of stilbene derivatives are particularly useful in suppressing tumor growth in vivo.

  Stilbene衍生物表现出对多种癌细胞的杀灭和抑制生长活性，并且在体内有效地抑制肿瘤生长。Stilbene衍生物可用于治疗以细胞过度增殖为特征的疾病，包括人类恶性肿瘤和非恶性疾病，如肝硬化。Stilbenes也可以破坏肿瘤中的异常血管，实现血管破坏效应以抑制肿瘤生长。水溶性的Stilbene衍生物前药形式在体内抑制肿瘤生长方面特别有用。
• [EN] POLYSUBSTITUTED BENZOFURANS AND MEDICINAL APPLICATIONS THEREOF<br/>[FR] BENZOFURANES POLYSUBSTITUÉS ET LEURS APPLICATIONS MÉDICINALES
  申请人：IKERCHEM S L

  公开号：WO2011141458A1

  公开（公告）日：2011-11-17

  The present invention refers to compounds of formula (I), as well as to a method for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or chemoprevention of cancer, aging related diseases or processes, diabetes and neurodegenerative diseases.

  本发明涉及式（I）的化合物，以及它们的制备方法、包含相同化合物的药物组合物，以及用于治疗和/或化学预防癌症、与衰老相关的疾病或过程、糖尿病和神经退行性疾病的用途。
• Polysubstituted benzofurans and medicinal applications thereof
  申请人：Ikerchem, S.L.

  公开号：EP2388255A1

  公开（公告）日：2011-11-23

  The present invention refers to compounds of formula (I): as well as to a method for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or chemoprevention of cancer, aging related diseases or processes, diabetes and neurodegenerative diseases.

  本发明涉及式（I）的化合物，以及它们的制备方法，包含它们的制药组合物，以及用于治疗和/或化学预防癌症、与衰老相关的疾病或过程、糖尿病和神经退行性疾病的用途。
• Methods and compositions for treatment of cancer and autoimmune disease
  申请人：THE JACKSON LABORATORY

  公开号：US10207988B2

  公开（公告）日：2019-02-19

  The technology described herein relates to methods of inducing cell death. The technology described herein further relates to treating conditions including cancers and autoimmune diseases comprising administering inhibitors of double strand break repair. Also described herein are inhibitors of double strand break repair and methods of screening for such inhibitors.

  本文所述技术涉及诱导细胞死亡的方法。本文所述技术还涉及通过施用双链断裂修复抑制剂来治疗包括癌症和自身免疫性疾病在内的疾病。本文还描述了双链断裂修复抑制剂和筛选此类抑制剂的方法。