daunorubicin | 57918-20-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 蒽环类药物
• 英文名称: daunorubicin
• 英文别名: (7S,9S)-9-acetyl-7-[(2S,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione
• CAS: 57918-20-4
• 化学式: C₂₇H₂₉NO₁₀
• 分子量: 527.528
• InChiKey: STQGQHZAVUOBTE-QTMANNMUSA-N

物化性质

• 沸点：
  770.0±60.0 °C(Predicted)
• 密度：
  1.55±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  38
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  186
• 氢给体数：
  5
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  daunorubicin 生成 (7S,9S)-7-[(2S,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-9-(2-bromoacetyl)-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione
  参考文献：
  名称：

  JIZBA, JOSEF;VANEK, ZDENKO;KRUMPHANZL, VLADIMIR;VONDRACEK, MILOSLAV

  摘要：

  DOI：

文献信息

• Pharmaceutical composition comprising microbubbles for targeted tumor therapy
  申请人：Ludwig-Maximilians-Universität München

  公开号：EP2253308A1

  公开（公告）日：2010-11-24

  The present invention relates to a pharmaceutical composition for the targeted delivery of a pharmaceutically active compound, the composition comprising soft, gas-filled particles having an envelope monolayer comprising one or more surfactants and a pharmaceutically active compound. More particularly, the invention relates to a pharmaceutical composition, wherein the envelope monolayer of the gas-filled particles have a negative overall net charge, and wherein the pharmaceutically active compound has a positive overall net charge and is directly bound to one or more surfactants by both electrostatic and hydrophobic interactions. The present invention also relates to a method of producing said pharmaceutical composition comprising the steps of providing a pharmaceutical active compound- loaded liposomal preparation and the subsequent formation of gas-filled particles by adding a pharmaceutically acceptable gas to the liposomal preparation. Furthermore, the invention relates to the use of said pharmaceutical composition in the treatment of tumors.

  本发明涉及一种用于靶向输送药物活性化合物的制药组合物，该组合物包括软性气体充填颗粒，其包膜单层包括一种或多种表面活性剂和药物活性化合物。更具体地，本发明涉及一种制药组合物，其中气体充填颗粒的包膜单层具有负的总净电荷，药物活性化合物具有正的总净电荷，并且通过静电和疏水相互作用直接结合在一种或多种表面活性剂上。本发明还涉及一种制备所述制药组合物的方法，包括提供药物活性化合物负载的脂质体制备和通过向脂质体制备中添加药用可接受气体形成气体充填颗粒的后续步骤。此外，本发明还涉及在肿瘤治疗中使用所述制药组合物的用途。
• PHARMACEUTICAL COMPOSITION FOR TREATING ACUTE MYELOID LEUKEMIA, CONTAINING FLT3 INHIBITOR AND CHEMOTHERAPEUTIC AGENTS
  申请人：Hanmi Pharm. Co., Ltd.

  公开号：EP3991733A1

  公开（公告）日：2022-05-04

  Provided are: a pharmaceutical composition for treating myeloid leukemia (AML), and a method for treating acute myeloid leukemia using same, the pharmaceutical composition comprising a therapeutically effective combination of an Fms-like tyrosine kinase-3 (FLT3) inhibitor or pharmaceutically acceptable salt or solvate thereof, and a chemotherapeutic agent or pharmaceutically acceptable salt or solvate thereof.

  提供了：一种用于治疗髓性白血病（AML）的药物组合物，以及一种使用该药物组合物治疗急性髓性白血病的方法，该药物组合物包含一种Fms样酪氨酸激酶-3（FLT3）抑制剂或其药学上可接受的盐或溶液，以及一种化疗剂或其药学上可接受的盐或溶液的治疗有效组合。
• Fucoidan nanogels and methods of their use and manufacture
  申请人：Memorial Sloan Kettering Cancer Center

  公开号：US10478506B2

  公开（公告）日：2019-11-19

  Described herein are polymeric drug-carrying nanogels that are capable of targeting to P-selectin for the treatment of cancer and other diseases and conditions associated with P-selectin. Furthermore, in certain embodiments, the nanogels presented here offer a drug release mechanism based on acidic pH in the microenvironment of a tumor, thereby providing improved treatment targeting capability and allowing use of lower drug doses, thereby reducing toxicity.

  本文描述的聚合物载药纳米凝胶能够靶向 P-选择素，用于治疗癌症和其他与 P-选择素相关的疾病和病症。此外，在某些实施方案中，本文介绍的纳米凝胶提供了一种基于肿瘤微环境中酸性pH值的药物释放机制，从而提高了治疗靶向能力，并允许使用较低的药物剂量，从而降低了毒性。
• TARASOVA, V. E.;ULYANOVA, L. A.;YUDINA, O. I.;GOLDBERG, L. E.;POVAROV, L.+, ANTIBIOTIKI I XIMIOTERAPIYA, 35,(1990) N, S. 21-24
  作者：TARASOVA, V. E.、ULYANOVA, L. A.、YUDINA, O. I.、GOLDBERG, L. E.、POVAROV, L.+

  DOI：——

  日期：——
• GAUDIANO, GIORGIO;FRIGERIO, MASSIMO;BRAVO, PIERFRANCESCO;KOCH, TAD H., J. AMER. CHEM. SOC., 112,(1990) N8, C. 6704-6709
  作者：GAUDIANO, GIORGIO、FRIGERIO, MASSIMO、BRAVO, PIERFRANCESCO、KOCH, TAD H.

  DOI：——

  日期：——