7,8-dihydroxyspiro[chromene-2,1'-cyclohexan]-4(3H)-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 7,8-dihydroxyspiro[chromene-2,1'-cyclohexan]-4(3H)-one
• 英文别名: 7,8-dihydroxyspiro[3H-chromene-2,1'-cyclohexane]-4-one
• 化学式: C₁₄H₁₆O₄
• mdl: MFCD08741817
• 分子量: 248.27
• InChiKey: VXZPJQXETDFJCN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Heterocyclic compounds, processes for producing them and pharmaceutical compositions comprising them
  申请人：SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD.

  公开号：EP0415566A1

  公开（公告）日：1991-03-06

  Novel heterocyclic compounds capable of lowenng the und acid levels in plasma and unne having the formula (I) wherein R2 and R2 are independently hydrogen, lower alkyl, phenyl or substituted phenyl, or R' and R2 may form a four to eight-membered carbon ring together with the carbon atom to which they are attached: R3is hydrogen or lower alkyl: R4 is one or two radicals selected from a group consisting of hydrogen, halogen, nitro. lower alkyl. phenyl. substituted phenyl, -OR5 and -SO2NR6R6; R5 is hydrogen. lower alkyl phenyl-substituted lower alkyl. carboxymethyl or ester thereof, hydroxethyl or ether thereof, or allyl; R6 and R6 are independently hydrogen or lower alkyl: R7 is hydrogen or a pharmaceutically active ester-forming group: A is a straight or branched hydrocarbon radical having one to five carbon atoms: B is halogen. oxygen, or dithiolane; Y is oxygen. sulfur, nitrogen or substituted nitrogen; Z is oxygen, nitrogen or substituted nitrogen: dotted line represents the presence or absence of a single bond, processes for their production and pharmaceutical compositions comprising them.

  能降低血浆和ne中und酸含量的新型杂环化合物，其式为(I) 其中 R2 和 R2 独立地为氢、低级烷基、苯基或取代苯基，或 R' 和 R2 可与所连接的碳原子一起形成四至八元碳环：R3 是氢或低级烷基：R4是一个或两个基团，选自由氢、卤素、硝基、低级烷基、苯基、取代苯基、-OR5和-SO2NR6R6组成的组；R5是氢、低级烷基苯基取代低级烷基、羧甲基或其酯、羟乙基或其醚或烯丙基；R6和R6独立地是氢或低级烷基：R7 是氢或药用活性酯形成基团：A 是具有 1 至 5 个碳原子的直链或支链烃基：B是卤素、氧或二硫环烷；Y是氧、硫、氮或取代的氮；Z是氧、氮或取代的氮：虚线表示存在或不存在单键，其生产工艺和包含它们的药物组合物。
• US5268386A
  申请人：——

  公开号：US5268386A

  公开（公告）日：1993-12-07