5,6-Dihydroxy-8,10-dimethoxy-2-propylbenzo[g]chromen-4-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并吡喃类
• 英文名称: 5,6-Dihydroxy-8,10-dimethoxy-2-propylbenzo[g]chromen-4-one
• 化学式: C₁₈H₁₈O₆
• 分子量: 330.3
• InChiKey: VZWQSVBLIULGBB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  85.2
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• METHOD OF INHIBITING ABCG2 AND OTHER TREATMENT METHODS
  申请人：The United States of America, as represented by the Secretary, Department of Health and Human

  公开号：US20130274323A1

  公开（公告）日：2013-10-17

  Disclosed are methods of enhancing the chemotherapeutic treatment of tumor cells, reducing resistance of a cancer cell to a chemotherapeutic agent, a method of inhibiting ABCG2, Pgp, or MRP1 in a mammal afflicted with cancer, and a method of increasing the bioavailability of an ABCG2 substrate drug in a mammal. The methods comprise administering effective amounts of certain compounds to the mammal, for example, a compound of the formula (I): wherein R 1 , R 2 , R 3 , X 1 , X 2 , X 3 , a, and b are as described herein. Uses of these compounds in the preparation of a medicament are also disclosed. Also disclosed are compounds of formula (II), pharmaceutical compositions comprising such compounds and uses thereof.
• US8470888B2
  申请人：——

  公开号：US8470888B2

  公开（公告）日：2013-06-25
• US9314448B2
  申请人：——

  公开号：US9314448B2

  公开（公告）日：2016-04-19