毒理性
◉ 母乳喂养期间使用总结：关于麦角胺在哺乳期的使用经验有限，它可能会对婴儿产生不良影响并减少乳汁供应。大多数权威机构认为哺乳期间应禁忌使用麦角胺。
◉ 对哺乳婴儿的影响：一项研究中，麦角胺在新生儿母亲分娩后立即以每日三次，每次1毫克，连续使用6天的剂量给药，发现对母乳喂养婴儿的体重增长没有影响。在母亲的乳汁完全下来之前的最初几天，乳汁摄入量可能很少，因此婴儿的剂量可能很小。
◉ 对泌乳和母乳的影响：30名分娩足月婴儿的妇女在分娩后接受了一次肌内注射甲基麦角新碱0.2毫克，随后口服麦角胺1毫克，每日三次，连续使用6天。与28名分娩足月婴儿且未接受任何麦角衍生物的妇女相比，两组在分娩后前6天的乳汁产量（通过哺乳前后体重的差异来衡量）没有差异。
◉ Summary of Use during Lactation:There is limited published experience with ergotamine during breastfeeding and it might cause adverse effects in the infant and decrease milk supply. Most authorities consider ergotamine to be contraindicated during nursing.
◉ Effects in Breastfed Infants:A study in which ergotamine was administered to mothers of newborns immediately postpartum in a dose of 1 mg 3 times daily for 6 days found no effect on weight gain in the breastfed infants. Milk intake, and therefore infant dosage, might have been minimal during the first few days before the mothers' milk came in fully.
◉ Effects on Lactation and Breastmilk:Thirty women who delivered fullterm infants received a single intramuscular dose of methylergonovine 0.2 mg after delivery, followed by oral ergotamine 1 mg 3 times daily for 6 days. Compared to 28 women who delivered fullterm infants and received no ergot derivatives, there was no difference in the milk production, as measured by weight differences before and after nursing, between the 2 groups during the first 6 days postpartum.
来源:Drugs and Lactation Database (LactMed)
