2-Amino-9-[5-o-(hydroxy{[hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl)pentofuranosyl]-3,9-dihydro-6h-purin-6-one

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 英文名称: 2-Amino-9-[5-o-(hydroxy{[hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl)pentofuranosyl]-3,9-dihydro-6h-purin-6-one
• 英文别名: [[5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
• 化学式: C₁₀H₁₆N₅O₁₄P₃
• 分子量: 523.18
• InChiKey: XKMLYUALXHKNFT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6.5
• 重原子数：
  32
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  295
• 氢给体数：
  8
• 氢受体数：
  15

反应信息

• 作为反应物：
  描述：

  2-Amino-9-[5-o-(hydroxy{[hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl)pentofuranosyl]-3,9-dihydro-6h-purin-6-one 在 盐酸 、 四丁基溴化铵 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 水 、 乙腈 为溶剂， 生成
  参考文献：
  名称：

  A NOVEL SMALL MOLECULE KRAS INHIBITOR: DRUGGING UNDRUGGABLE TARGETS FOR CANCER THERAPEUTICS

  摘要：

  The present invention discloses a anticancer activity exhibiting compound of structural formula I : Formula I or a pharmaceutically acceptable salt thereof; in which ▪ W is selected from a group comprising of substituted saturated/unsaturated branched/linear aliphatic amine, substituted aromatic amine, unsubstituted saturated/unsaturated branched/linear aliphatic amine, unsubstituted aromatic amine; ▪ X is selected from a group comprising of H, substituted/unsubstituted saturated/unsaturated branched/linear aliphatic alkyl group with atleast one carbon atom, substituted/unsubstituted saturated/unsaturated branched/linear aliphatic alkoxy group with atleast one carbon atom, substituted/unsubstituted aryl group, substituted/unsubstituted aryloxy group; ▪ Y is selected from a group comprising of H, substituted/unsubstituted saturated/unsaturated branched/linear aliphatic alkyl group bonded to a carbonyl group, substituted/unsubstituted aryl group bonded to a carbonyl group; ▪ Z is selected from a group comprising of H, OH.

  公开号：

  WO2024127214A1

文献信息

• Methods for modulating taste receptors
  申请人：MARS, INCORPORATED

  公开号：US11185100B2

  公开（公告）日：2021-11-30

  Amino acids present in domains of an umami taste receptor are described herein, wherein the amino acids interact with at least one nucleotide derivative and/or at least one transmembrane compound that potentiates, modulates, increases, and/or enhances the activity of the umami receptor. Such compounds can be used in flavor compositions to enhance the umami taste and/or palatability of food products.

  本文描述了存在于鲜味受体结构域中的氨基酸，其中氨基酸与至少一种核苷酸衍生物和/或至少一种跨膜化合物相互作用，从而增强、调节、增加和/或提高鲜味受体的活性。此类化合物可用于调味组合物，以增强食品的鲜味和/或适口性。
• Pathway Analysis of Cell Culture Phenotypes and Uses Thereof
  申请人：Melville Mark

  公开号：US20090186358A1

  公开（公告）日：2009-07-23

  The present invention provides methods for systematically identifying genes, proteins and/or related pathways that regulate or indicative of cell phenotypes. The present invention further provides methods for manipulating the identified genes, proteins and/or pathways to engineer improved cell lines and/or to evaluate or select cell lines with desirable phenotypes.
• COMBINATION OF SKIN PROTECTION AGAINST DAMAGES CAUSED BY INFRARED RADIATION
  申请人：Hypermarcas S.A.

  公开号：US20150366777A1

  公开（公告）日：2015-12-24

  A combination of at least one SIRT1 peptide activator and at least one guanosine derivative alarmone, in a dermatological cosmetic for providing protection against damages caused by infrared radiation.
• MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF
  申请人：Moderna Therapeutics, Inc.

  公开号：US20160348099A1

  公开（公告）日：2016-12-01

  The present disclosure provides modified nucleosides, nucleotides, and nucleic acids, and methods of using them.
• Inorganic-organic hybrid compound
  申请人：Karlsruher Institut für Technologie

  公开号：US20170112948A1

  公开（公告）日：2017-04-27

  The present invention relates to an inorganic-organic hybrid compound as ionic compound, composed of an inorganic cation and of an organic active ingredient anion and also, optionally, of an organic fluorescent dye anion.