2-hydroxy-2-[(4-hydroxyphenyl)methyl]butanedioic Acid | 42151-32-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: 2-hydroxy-2-[(4-hydroxyphenyl)methyl]butanedioic Acid
• CAS: 42151-32-6
• 化学式: C₁₁H₁₂O₆
• 分子量: 240.21
• InChiKey: XLGKDRSWPCQYAB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  115
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• CRYSTAL OF EUCOMIC ACID NON-SOLVATE AND PRODUCTION METHOD THEREFOR
  申请人：Kyowa Hakko Bio Co., Ltd.

  公开号：EP3822249A1

  公开（公告）日：2021-05-19

  An object of the present invention is to provide a non-solvate crystal of eucomic acid having a low methanol content and excellent fluidity, and a method for producing the same. The present invention can provide a non-solvate crystal of eucomic acid having a low methanol content and excellent fluidity by drying a methanol solvate crystal of eucomic acid.

  本发明的目的是提供一种甲醇含量低、流动性好的非溶解性优可酸晶体，以及生产这种晶体的方法。本发明可以通过干燥优可酸的甲醇溶物晶体，提供甲醇含量低、流动性好的优可酸非溶物晶体。
• Non-solvate crystal of eucomic acid and method for producing same
  申请人：KYOWA HAKKO BIO CO., LTD.

  公开号：US11365170B2

  公开（公告）日：2022-06-21

  An object of the present invention is to provide a non-solvate crystal of eucomic acid having a low methanol content and excellent fluidity, and a method for producing the same. The present invention can provide a non-solvate crystal of eucomic acid having a low methanol content and excellent fluidity by drying a methanol solvate crystal of eucomic acid.

  本发明的目的是提供一种甲醇含量低、流动性好的非溶解性优可酸晶体，以及生产这种晶体的方法。本发明可以通过干燥优可酸的甲醇溶物晶体，提供甲醇含量低、流动性好的优可酸非溶物晶体。
• COMPOSITION COSMETIQUE
  申请人：Guerlain

  公开号：EP2556080A1

  公开（公告）日：2013-02-13
• COSMETIC COMPOSITION
  申请人：Simmler Charlotte

  公开号：US20130157968A1

  公开（公告）日：2013-06-20

  The invention relates to novel eucomic acid (2-(4-hydroxybenzyl)malic acid) derivatives or plant extracts comprising such derivatives, and also to cosmetic or dermatological compositions containing these compounds or these extracts, and to cosmetic care methods using said compositions. Exemplary compounds are represented by formula (I) below: in which, with the proviso that R 1 , R 2 and R 3 are not simultaneously a hydrogen atom, R 1 and R 3 each independently represent a hydrogen atom or a saturated or unsaturated, preferably C 1 -C 12 , hydrocarbon-based chain comprising an aromatic group, preferably a phenyl, said aromatic group being preferably substituted with a group comprising a sugar, preferably a monosaccharide or disaccharide, said chain optionally also comprising one or more heteroatoms preferably chosen from O, S and N, and R 2 represents a hydrogen atom or a sugar, preferably a monosaccharide or disaccharide, said sugar being optionally substituted, in particular with a residue comprising a saturated or unsaturated, preferably C 1 -C 12 , hydrocarbon-based chain itself comprising an aromatic group, preferably a phenyl, said hydrocarbon-based chain optionally also comprising one or more heteroatoms preferably chosen from O, S and N.
• NON-SOLVATE CRYSTAL OF EUCOMIC ACID AND METHOD FOR PRODUCING SAME
  申请人：KYOWA HAKKO BIO CO., LTD.

  公开号：US20210221764A1

  公开（公告）日：2021-07-22

  An object of the present invention is to provide a non-solvate crystal of eucomic acid having a low methanol content and excellent fluidity, and a method for producing the same. The present invention can provide a non-solvate crystal of eucomic acid having a low methanol content and excellent fluidity by drying a methanol solvate crystal of eucomic acid.