2-Methyl-3'-methoxy-4'-hydroxyphenylpropionic acid | 65632-79-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: 2-Methyl-3'-methoxy-4'-hydroxyphenylpropionic acid
• 英文别名: 3-(4-hydroxy-3-methoxy-phenyl)-2-methyl-propionic acid；3-(4-Hydroxy-3-methoxy-phenyl)-2-methyl-propionsaeure；Hydrohomoferulasaeure；3-(4-Hydroxy-3-methoxyphenyl)-2-methylpropanoic acid
• CAS: 65632-79-3
• 化学式: C₁₁H₁₄O₄
• 分子量: 210.23
• InChiKey: XUQXZROVMZNKPO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  α-methyl-(E)-ferulic acid 在 sodium amalgam 作用下， 生成 2-Methyl-3'-methoxy-4'-hydroxyphenylpropionic acid
  参考文献：
  名称：

  Tiemann; Kraaz, Chemische Berichte, 1882, vol. 15, p. 2063

  摘要：

  DOI：

文献信息

• Photoredox Activation of Formate Salts: Hydrocarboxylation of Alkenes via Carboxyl Group Transfer
  作者：Yan Huang、Jing Hou、Le-Wu Zhan、Qian Zhang、Wan-Ying Tang、Bin-Dong Li

  DOI：10.1021/acscatal.1c04684

  日期：2021.12.17

  reagent, a wide range of alkenes can be converted into acid products via a carboxyl group transfer strategy in an additive-free fashion. Mechanistic studies revealed that radical anion species (CO2•– and carbon radical anions derived from the reduction of alkenes) are key intermediates of the transformation. This method has the advantages of high catalytic efficiency and a simple catalytic system, which

  开发了用于羧化的甲酸盐的光氧化还原活化模式。使用甲酸盐作为还原剂、羰基源和氢原子转移试剂，可以通过羧基转移策略以无添加剂的方式将各种烯烃转化为酸性产物。机理研究表明自由基阴离子物质（CO 2 •–和来自烯烃还原的碳自由基阴离子）是转化的关键中间体。该方法具有催化效率高、催化体系简单等优点，有望成为一种有前景的工业应用策略。
• METHOD FOR DIAGNOSING IN VITRO OR EX VIVO PSYCHIATRIC DISORDERS AND/OR INTESTINAL DYSBIOSES
  申请人：Chery Celine

  公开号：US20100028901A1

  公开（公告）日：2010-02-04

  The invention relates to the use of at least one of the following Formula (I) compounds: wherein n=1, Ra notably represents —COOH, Rb notably represents —CH 3 —, Z notably represents —CH 2 —CHOH—, wherein the compound may be in the form of salts or, if at least one asymmetric carbon atom is present, in the form of isolated isomers or as a racemic mixture, as a physiological marker for carrying out a method for the in vitro or ex vivo diagnosis of psychiatric disorders and/or intestinal dysbioses.
• Tiemann; Kraaz, Chemische Berichte, 1882, vol. 15, p. 2063
  作者：Tiemann、Kraaz

  DOI：——

  日期：——