1-Hydroxy-6,6,9-trimethyl-3-pentyl-6a,7,10,10a-tetrahydrobenzo[c]chromene-2-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 1-Hydroxy-6,6,9-trimethyl-3-pentyl-6a,7,10,10a-tetrahydrobenzo[c]chromene-2-carboxylic acid
• 英文别名: 1-hydroxy-6,6,9-trimethyl-3-pentyl-6a,7,10,10a-tetrahydrobenzo[c]chromene-2-carboxylic acid
• 化学式: C₂₂H₃₀O₄
• 分子量: 358.5
• InChiKey: YKKHSYLGQXKVMO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] CANNABINOID ACID ESTER COMPOSITIONS AND USES THEREOF<br/>[FR] COMPOSITIONS D'ESTER D'ACIDE CANNABINOÏDE ET LEURS UTILISATIONS
  申请人：EPM GROUP INC

  公开号：WO2021034403A1

  公开（公告）日：2021-02-25

  The present disclosure provides pharmaceutical compositions including a cannabinoid acid ester compound alone or in combination with one or more additional cannabinoid compounds. In some embodiments, the cannabinoid acid ester compound is a tetrahydrocannabinolic acid (THCA) ester. In some embodiments, the cannabinoid acid ester compound is a cannabigerolic (CBGA) acid ester. In some embodiments, the cannabinoid acid ester compound is a cannabinolic (CBNA) acid ester. A variety of therapeutic applications in which the cannabinoid acid ester compounds and pharmaceutical compositions find use are also provided, including combination therapies using cannabinoid acid ester compounds and one or more additional therapeutic agents.

  本公开提供了包含一种大麻酸酯化合物的药物组合物，该化合物单独或与一个或多个额外的大麻化合物结合使用。在某些实施例中，大麻酸酯化合物是四氢大麻酸（THCA）酯。在某些实施例中，大麻酸酯化合物是大麻二酚酸（CBGA）酯。在某些实施例中，大麻酸酯化合物是大麻酚（CBNA）酯。还提供了大麻酸酯化合物和药物组合物在各种治疗应用中的用途，包括使用大麻酸酯化合物和一个或多个额外治疗剂的联合疗法。
• Prenyltransferase variants with increased thermostability
  申请人：INVIZYNE TECHNOLOGIES, INC.

  公开号：US11518983B1

  公开（公告）日：2022-12-06

  The present disclosure relates to recombinant prenyltransferase enzymes with increased thermostability and activity and the use of these enzymes in compositions and methods for biosynthesis involving prenylation reactions, including compositions and methods for the preparation of cannabinoids.

  本公开涉及具有更高热稳定性和活性的重组炔基转移酶，以及这些酶在涉及炔基 化反应的生物合成的组合物和方法中的用途，包括制备大麻素的组合物和方法。
• EXTRACTION METHOD AND COMPOSITION OBTAINED THEREFROM
  申请人：NATURALIA INGREDIENTS S.r.l

  公开号：EP3894036A2

  公开（公告）日：2021-10-20
• CANNABINOID ACID ESTER COMPOSITIONS AND USES THEREOF
  申请人：EPM Group, Inc.

  公开号：EP4017485A1

  公开（公告）日：2022-06-29
• RECOMBINANT ACYL ACTIVATING ENZYME (AAE) GENES FOR ENHANCED BIOSYNTHESIS OF CANNABINOIDS AND CANNABINOID PRECURSORS
  申请人：Willow Biosciences, Inc.

  公开号：US20220186231A1

  公开（公告）日：2022-06-16

  The present disclosure provides recombinant host cells comprising a pathway capable of producing a cannabinoid and/or cannabinoid precursor, wherein the pathway comprises an enzyme AAE from a source organism other than Cannabis sativa , such as Humulus lupulus . The disclosure also provides methods of using the host cells to produce rare cannabinoids and/or rare cannabinoid precursors.