2-(Hydroxymethyl)-6-[2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethyl]phenoxy]oxane-3,4,5-triol

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 2-(Hydroxymethyl)-6-[2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethyl]phenoxy]oxane-3,4,5-triol
• 英文别名: 2-(hydroxymethyl)-6-[2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethyl]phenoxy]oxane-3,4,5-triol
• 化学式: C₂₄H₃₂O₁₀
• 分子量: 480.5
• InChiKey: ZXLBAXILFSXOEX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  34
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  136
• 氢给体数：
  4
• 氢受体数：
  10

文献信息

• [EN] ERIANIN DERIVATIVES AND USE THEREOF<br/>[FR] DÉRIVÉS D'ÉRIANINE ET LEUR UTILISATION
  申请人：UNIV HONG KONG

  公开号：WO2019020072A1

  公开（公告）日：2019-01-31

  Erianin derivatives according to Formula (I), and pharmaceutical compositions thereof, are provided for treating cancer including hepatocarcinoma, melanoma, osteosarcoma and promyelocytic leukemia. The Erianin derivatives is Erianin-based core conjugated to a functional moiety by a cleavable linker. The functional moiety is a water-soluble small molecule or a targeting antigen. The functional moiety is preferably polyethylene glycol (PEG).